NCT05527535

Brief Summary

Efficiency and effectiveness of real-world diabetic retinopathy screening by artificial intelligent (AI) are limited. Investigators will implement AI for diabetic retinopathy screening in 13 health districts in Thailand and investigate the efficiency, effectiveness as well as patients and health care personnel's satisfaction by an implementation research.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
34,500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2022

Shorter than P25 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 25, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 2, 2022

Completed
1 month until next milestone

Study Start

First participant enrolled

October 3, 2022

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2023

Completed
Last Updated

September 2, 2022

Status Verified

August 1, 2022

Enrollment Period

6 months

First QC Date

August 25, 2022

Last Update Submit

August 31, 2022

Conditions

Keywords

Diabetic Retinopathy, Screening, Deep Learning Algorithm, Human Grader

Outcome Measures

Primary Outcomes (3)

  • Effectiveness of AI in diabetic retinopathy screening

    Referral adherance of patients in AI group in percentage

    Throughout the whole period of screening, approximately 6 months

  • Efficiency of AI in diabetic retinopathy screening

    Down time and failure rate of AI system

    Throughout the whole period of screening, approximately 6 months

  • Efficiency of AI in diabetic retinopathy screening

    Cost in development and implement of AI system in Thai baht unit

    Throughout the whole period of screening, approximately 6 months

Secondary Outcomes (1)

  • Satisfaction of patients and health care personnel in AI-based screening

    At the end of the screening, approximately at Month 6

Study Arms (2)

AI screening group

Diabetes mellitus patients undergo diabetic retinopathy screening by AI

Diagnostic Test: Diabetic retinopathy screening by artificial intelligence

Manual screening group

Diabetes mellitus patients undergo diabetic retinopathy screening by health care personnel

Diagnostic Test: Diabetic retinopathy screening by healthcare personnel

Interventions

Screening diabetic patients' eyes with AI through digital health platform

AI screening group

Screening diabetic patients' eyes by conventional method (healthcare personnel)

Manual screening group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All diabetes mellitus patients who visit for diabetic retinopathy screening at selected primary care units and hospitals in 13 health districts in Thailand

You may qualify if:

  • Type 1 or 2 diabetes mellitus patients whose name are in primary hospital record
  • No full-time ophthalmologists in those primary hospital
  • Age more than or equal to 18 years
  • Eligible for fundus photo imaging at least 1 eye

You may not qualify if:

  • Type 1 or 2 diabetes mellitus patients whose name are in primary hospital record that have full-time ophthalmologists
  • Patients who previously diagnosed with other causes of macular edema, for example, Age-related Macular Degeneration, Radiation Retinopathy, Retinal Vein Occlusion etc.
  • History of retinal laser or surgery
  • Other ocular diseases that require referral to ophthalmologists
  • Not eligible for fundus photo imaging for both eyes (any causes)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Diabetic Retinopathy

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System Diseases

Central Study Contacts

Paisan Ruamviboonsuk, Dr.

CONTACT

Methaphon Chainakul, Dr.

CONTACT

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 25, 2022

First Posted

September 2, 2022

Study Start

October 3, 2022

Primary Completion

March 31, 2023

Study Completion

September 30, 2023

Last Updated

September 2, 2022

Record last verified: 2022-08

Data Sharing

IPD Sharing
Will not share

Fear of inappropriate use of data