PROgnostic Value of MicroParticles and Markers of Hemostasis in TIA and Ischemic Stroke

NCT05524506 | Completed

• 1 other identifier: KIDS-IM-LL-2016-01
• Study Type: observational
• Target: 249
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose is to investigate if different microparticles and markers of hemostasis predict outcome after TIA or ischemic stroke and to study the association between these variables and stroke subtype or etiology.

Conditions

Brain Ischemia; Cerebral Ischemia; Extracellular Vesicles; Hemostasis; Prognosis

Keywords

Ischemic stroke; TIA; Microparticles; Markers of hemostasis; Stroke etiology

Outcome Measures

Primary Outcomes (1)

• Fatal or non-fatal ischemic stroke or myocardial infarction.

  New fatal or non-fatal ischemic stroke after the initial ischemic stroke or TIA leading to recruitment. Outcome events and time of events are extracted from national registries ('Patientregistret', 'Dödsorsaksregistret') and hospital records.

  2007-2014

Secondary Outcomes (2)

• Recurrent ischemic stroke

  2007-2014

• All-cause mortality

  2007-2014

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients from two hospital stroke units in Stockholm having suffered ischemic stroke or TIA 2007-2009 without known atrial fibrillation and able to handle handheld ECG-recorder.

You may qualify if:

• acute ischemic stroke or TIA less than 2 weeks before enrollment
• ability to understand study instructions both verbal and written
• ability to handle handheld ECG

You may not qualify if:

• known atrial fibrillation
• hemorrhagic stroke at time of enrollment
• limited compliance
• pacemaker

Sponsors & Collaborators

• Karolinska Institutet: lead
• Danderyd Hospital: collaborator
• Stockholm South General Hospital: collaborator

Study Sites (1)

Karolinska Institutet, Daderyd Hospital

Stockholm, S-182 88, Sweden

Location

Related Publications (2)

• Lundstrom A, Mobarrez F, Rooth E, Thalin C, von Arbin M, Henriksson P, Gigante B, Laska AC, Wallen H. Prognostic Value of Circulating Microvesicle Subpopulations in Ischemic Stroke and TIA. Transl Stroke Res. 2020 Aug;11(4):708-719. doi: 10.1007/s12975-019-00777-w. Epub 2020 Jan 25.

  PMID: 31983048 BACKGROUND

• Lundstrom A, Anggardh-Rooth E, Mobarrez F, Thalin C, Gigante B, Laska AC, Wallen H. High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study. Thromb Haemost. 2021 May;121(5):584-593. doi: 10.1055/s-0040-1721146. Epub 2020 Dec 12.

  PMID: 33314013 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Platelet-poor plasma (citrated and EDTA)

MeSH Terms

Conditions

Brain Ischemia; Ischemic Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Stroke

Study Officials

• Mårten Rosenqvist, Prof

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: September 23, 2020
• First Posted: September 1, 2022
• Study Start: June 1, 2007
• Primary Completion: December 1, 2014
• Study Completion: June 30, 2021
• Last Updated: September 1, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)