NCT05522712

Brief Summary

Valvular heart disease (VHD) is a growing and important public health problem due to the increasing prevalence of degenerative VHD, accompanied by prolonged life expectancy in developed countries. It is associated with high morbidity and mortality.Heart valve surgery is one of the proven treatments of VHD, which corrects hemodynamic abnormalities that could contribute to decrease mortality and improvement in quality of life, despite the improvement in the hemodynamic parameters, the cardiorespiratory fitness level remained low after heart valve surgery. Cardiac surgeries can cause a series of clinical and functional complication. Postoperative pulmonary complications are the most common, in turn, contribute directly to increase morbidity and mortality and longer hospital stays.Mucociliary clearance is affected after open-heart surgery by the effects of general anaesthesia, intubation and analgesia. Expiratory flow rate is directly related to lung volume and therefore when lung volumes are decreased, coughing will be less effective. Chest physical therapy plays an important role in the prevention and management of postoperative pulmonary complications. It includes deep breathing exercises, mobilization, postural drainage, percussion and vibration or shaking which were developed to improve bronchial drainage. Airway clearance techniques are commonly used for clearing secretions, improving gas exchange, oxygenation, and work of breathing. Acapella® is an airway clearance device that combines the resistive features of a positive expiratory pressure device with oscillations which diminishes the mucus adhesiveness and decrease the collapsibility of airways. In the present study, the aim is to compare the effect of acapella and incentive spirometer on cardiopulmonary fitness in patients undergoing heart valve surgery. Those patients may gain a more benefit from acapella application and incentive spirometer so, prevent post-operative pulmonary complication, reduce hospitalization and hospital costs, and improve quality of life. Therefore, early mobilization and chest physiotherapy including acapella and incentive will be started on 1st day after discharge from cardiac care unit (CCU) .

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2022

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2022

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

August 20, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

August 31, 2022

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2023

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2023

Completed
Last Updated

August 31, 2022

Status Verified

August 1, 2022

Enrollment Period

1 year

First QC Date

August 20, 2022

Last Update Submit

August 30, 2022

Conditions

Outcome Measures

Primary Outcomes (6)

  • Pulmonary function test

    Forced vital capacity and forced expiratory volume in one second will be measured

    7 days

  • Peripheral oxygen saturation

    Determine level of oxygen in blood

    7 days

  • Rate of perceived exertion

    Dysnpea level measured by modified borg scale from 0 to 10 0 no dyspnea at all 10 maximal degree of dyspnea

    7 days

  • Pain intensity

    Measured by visual analogue scale to determine degree of incisional pain 0 no pain 10 worst pain

    7 days

  • Cardiorespiratory fitness evaluation

    Vo2max is measured to determine functional capacity after operation

    7 days

  • Length of hospital stay

    Determine how many days patient need to be in hospital and become fully hemodynamically stable

    Average 4 - 7 days

Study Arms (3)

Acapella user

EXPERIMENTAL

this group will use acapella in addition to traditional chest physiotherapy , early mobility and sternal precautions.

Device: Acapella user

Incentive spirometer user

EXPERIMENTAL

this group will receive incentive spirometer in addition to traditional chest physiotherapy, early mobility and sternal precautions.

Device: Incentive spirometer user

Control user

OTHER

this group will receive traditional chest physiotherapy , early mobility and sternal precautions.

Procedure: Control

Interventions

The exercise session will include three sets of deep breaths. Each set will include 10 repetitions which were fol¬lowed by 30 to 60 seconds pause in between. Patients will be instructed to perform slow maximal inspiration, while expiration was done through acapella in a prolonged manner to minimize airway closure and alveolar collapse. In the Acapella device, resistance was increased continuously on each successive day. The technique will be applied for 15 minutes. Components of Acapella® treatment will include : * Breathing control * 10 breaths through the Acapella® device * Inhaling up to approximately three - quarter maximum breathing capacity * 2-3 second breath hold * Active exhalation to Functional residual capacity but not too forcefully (3-4 second) * The patient did 2-3 huffs at the end of the session, Cough or forced expiration in a set cycle.

Acapella user

1. Sit upright in a chair or in bed. Hold the incentive spirometer at eye level, hold a pillow to help splint or brace the incision to decrease pain at incision. 2. Put the mouthpiece in mouth and close lips tightly around it. Slowly breathe out (exhale) completely. 3. Breathe in (inhale) slowly through mouth as deeply as possible. As taking the breath, the ball will rise. 4. Try to get the ball as high as possible. 5. When getting it, hold breath for 10 seconds, or as long as possible. 6. Then, breathe out slowly through mouth. Then, Rest for a 30-60 seconds. 7. Repeat 10 times. Try to get the ball to the same level or higher with each breath. 8. repeat 10 times for 3 sets.

Incentive spirometer user
ControlPROCEDURE

This group is a control group will not receive new intervention just traditional chest physiotherapy and mobilization

Control user

Eligibility Criteria

Age30 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients of both sexes with age ranges (30-40) years old.
  • Patients with normal body mass index ranges (18.5-24.9) kg/m2
  • Patients undergo mitral valve surgery via median sternotomy.
  • Post operative, extubated heart valve surgery patients, who were able to follow the instructions and sign the consent form.
  • Patients with hemodynamic stability.
  • Patients with controlled diabetes mellitus.

You may not qualify if:

  • \- Patients who required more than 48 hours of intubation after surgery.
  • Reintubation in post operative period.
  • Patients who had history of respiratory tract infection within a period of three months.
  • Patients undergo CABG ,or double valve surgery.
  • Patients with any neuromuscular disease.
  • Patients with severe renal dysfunction.
  • Anemic patients.
  • Uncontrolled diabetes mellitus.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of physical therapy

Giza, Dokki, 12613, Egypt

RECRUITING

MeSH Terms

Conditions

Heart Valve DiseasesHeart Diseases

Condition Hierarchy (Ancestors)

Cardiovascular Diseases

Study Officials

  • Zeinab M. Helmy, PhD

    Cairo University

    STUDY CHAIR

Central Study Contacts

El sayed Essam El sayed, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

August 20, 2022

First Posted

August 31, 2022

Study Start

January 1, 2022

Primary Completion

January 1, 2023

Study Completion

March 30, 2023

Last Updated

August 31, 2022

Record last verified: 2022-08

Data Sharing

IPD Sharing
Will not share

Locations