Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury

NCT05513911 | Completed

• 1 other identifier: STU00201602
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH

Conditions

Spinal Cord Injuries

Keywords

Acute Intermittent Hypoxia; Motor Unit; Upper Extremity

Outcome Measures

Primary Outcomes (1)

• Maximal Elbow Strength [Newtons]

  Recordings of the elbow joint torque are taken while the participant is asked to flex and extend the elbow voluntarily at a maximum level of intensity

  30 minutes Post intervention

Secondary Outcomes (1)

• Biceps Brachii Muscle activation [μv]

  30 minutes post intervention

Study Arms (1)

Acute intermittent Hypoxia Therapy

EXPERIMENTAL

This group will receive the acute intermittent hypoxia therapy (9% O2) for 30 minutes. Before and after the intervention the participant will perform flexion of the elbow at various levels of intensity

Other: Acute Intermittent Hypoxia

Interventions

Acute Intermittent Hypoxia OTHER

Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session

Also known as: AIH

Acute intermittent Hypoxia Therapy

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• History of Spinal Cord Injury from C3-T4
• Non-progressive spinal cord injury
• More than 6 months since initial Spinal Cord injury
• Ability to understand and willingness to sign written informed consent

You may not qualify if:

• Presence of any of the following medical conditions: Congestive heart failure, arrhythmia, uncontrolled high blood pressure, uncontrolled diabetes mellitus, COPD/emphysema and severe asthma
• Persons with known coronary artery disease, a history of myocardial infarction, or known carotid or intracerebral artery stenosis
• Medical clearance will be required if participant is taking any other investigational agents
• Women who are pregnant or nursing
• Individuals with tracheostomy
• Cannot pursue other research studies which may interfere
• Unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Prisoners

Sponsors & Collaborators

• Shirley Ryan AbilityLab: lead

Study Sites (1)

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Spinal Cord Injuries

Interventions

Insemination, Artificial, Homologous

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Insemination, Artificial; Reproductive Techniques, Assisted; Reproductive Techniques; Therapeutics; Investigative Techniques; Insemination; Reproduction; Reproductive Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Study Officials

• William Z Rymer, MD, PhD

  Shirley Ryan AbilityLab

  PRINCIPAL INVESTIGATOR

• Milap Sandhu, PhD

  Shirley Ryan AbilityLab

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Every participant in this study will receive the intervention

Study Record Dates

• First Submitted: August 22, 2022
• First Posted: August 24, 2022
• Study Start: February 3, 2016
• Primary Completion: November 8, 2016
• Study Completion: March 25, 2019
• Last Updated: August 24, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)