NCT05508425

Brief Summary

To assess the effect of water temperature and additives on pregnant women's taste and side effect during the oral glucose tolerance test (OGTT) evaluation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
400

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2021

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 5, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 5, 2022

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

August 10, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

August 19, 2022

Completed
Last Updated

August 19, 2022

Status Verified

August 1, 2022

Enrollment Period

8 months

First QC Date

August 10, 2022

Last Update Submit

August 17, 2022

Conditions

Outcome Measures

Primary Outcomes (12)

  • Glycaemia level

    Glycaemia level just before glucose administration

    Glycaemia level was measured just before glucose administration.

  • Glycaemia level

    Glycaemia level at 1 hour after glucose administration

    Glycaemia level was measured at 1 hour after glucose administration

  • Glycaemia level

    Glycaemia level at 2 hour after glucose administration

    Glycaemia level was measured at 2 hours after glucose administration

  • gestational diabetes mellitus

    gestational diabetes mellitus just before glucose administration.

    Just before glucose administration.

  • gestational diabetes mellitus

    gestational diabetes mellitus at 1 hour after glucose administration.

    At 1 hour after glucose administration

  • gestational diabetes mellitus

    gestational diabetes mellitus at 2 hour after glucose administration.

    At 2 hour after glucose administration

  • Satisfaction after glucose solution administration

    Satisfaction was measured by a questionnaire using 5-point Likert scale (1: very dissatisfied; 2: dissatisfied; 3: neutral; 4: satisfied; 5: very satisfied).

    Just after glucose administration

  • Taste after glucose solution administration

    Taste was measured by a questionnaire using 5-point Likert scale (1: very dissatisfied; 2: dissatisfied; 3: neutral; 4: satisfied; 5: very satisfied).

    Just after glucose administration

  • Nausea after glucose solution administration

    Nausea was measured by a questionnaire using 5-point Likert scale (1: not at all; 2: slightly; 3: neutral; 4: serious; 5: very serious)

    Just after glucose administration

  • Vomiting after glucose solution administration

    Vomiting was measured by a questionnaire using 5-point Likert scale (1: not at all; 2: slightly; 3: neutral; 4: serious; 5: very serious)

    Just after glucose solution administration

  • Headache after glucose solution administration

    Headache was measured by a questionnaire using 5-point Likert scale (1: not at all; 2: slightly; 3: neutral; 4: serious; 5: very serious)

    Just after glucose solution administration

  • Abdominal bloating after glucose solution administration

    Abdominal bloating was measured by a questionnaire using 5-point Likert scale (1: not at all; 2: slightly; 3: neutral; 4: serious; 5: very serious)

    Just after glucose solution administration

Study Arms (8)

water at room temperature

ACTIVE COMPARATOR
Diagnostic Test: oral glucose tolerance test using water at room temperature

hot water

EXPERIMENTAL
Diagnostic Test: oral glucose tolerance test using hot water

cold water

EXPERIMENTAL
Diagnostic Test: oral glucose tolerance test using cold water

hot water with tea bag

EXPERIMENTAL
Diagnostic Test: oral glucose tolerance test using hot water with tea bag

room temperature water with tea bag

EXPERIMENTAL
Diagnostic Test: oral glucose tolerance test using room temperature water with tea bag

cold water with tea bag

EXPERIMENTAL
Diagnostic Test: oral glucose tolerance test using cold water with tea bag

bubble water at room temperature

EXPERIMENTAL
Diagnostic Test: Oral glucose tolerance test using bubble water at room temperature

cold bubble water

EXPERIMENTAL
Diagnostic Test: Oral glucose tolerance test using bubble water

Interventions

The use of water at room temperature to solve the 75g glucose.

water at room temperature

The use of hot water to solve the 75g glucose.

hot water

The use of cold water to solve the 75g glucose.

cold water

The use of hot water with tea bag to solve the 75g glucose.

hot water with tea bag

The use of room temperature water with tea bag to solve the 75g glucose.

room temperature water with tea bag

The use of cold water with tea bag to solve the 75g glucose.

cold water with tea bag

The use of bubble water at room temperature to solve the 75g glucose.

bubble water at room temperature

The use of cold bubble water to solve the 75g glucose.

cold bubble water

Eligibility Criteria

Age20 Years - 50 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Pregnant women
  • Gestational age between 24 and 28 weeks

You may not qualify if:

  • Clinical diagnosis of overt type 2 diabetes
  • Clinical diagnosis of facial palsy
  • Clinical diagnosis of oral cavity and throat
  • Clinical diagnosis of hypothyroidism
  • Clinical diagnosis of chronic hepatitis
  • Clinical diagnosis of kidney disease .Clinical diagnosis of Sicca syndrome.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ditmanson Medical Foundation Chia-Yi Christian Hospital

Chiayi City, Taiwan

Location

Related Publications (1)

  • Wang P, Chang PC, Wang CY, Wang LC, Shih CL. Comparing the effects of water temperature and additives in glucose solution on pregnant women's taste, side effects, and glycemic levels during an oral glucose tolerance test: a randomized controlled trial. Am J Obstet Gynecol MFM. 2023 Apr;5(4):100870. doi: 10.1016/j.ajogmf.2023.100870. Epub 2023 Jan 20.

MeSH Terms

Conditions

Diabetes, Gestational

Condition Hierarchy (Ancestors)

Pregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 10, 2022

First Posted

August 19, 2022

Study Start

November 1, 2021

Primary Completion

July 5, 2022

Study Completion

July 5, 2022

Last Updated

August 19, 2022

Record last verified: 2022-08

Data Sharing

IPD Sharing
Will not share

Locations