Regulation of Inflammatory Genes in Hidradenitis Suppurativa

NCT05507125 | Recruiting

• 1 other identifier: IRB-300006000
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this protocol is to examine the cytokine profi le of pati ents with hidradeniti s suppurati va (HS) and idemechanisms responsible for post-transcripti onal regulati on of these genes. The primary objecti ve is to determinfollowing cytokines linked to hidradeniti s suppurati va are diff erenti ally expressed in hidradeniti s pati ents versus controlalso doing a sub-study to determine the eff ect of childhood trauma on HS. The parti cipati on in the sub-study is opti onal

Conditions

Hidradenitis Suppurativa

Outcome Measures

Primary Outcomes (1)

• Inflammatory biomarkers

  Inflammatory biomarkers

  24 hours after application

Secondary Outcomes (1)

• Cytokines

  24 hours after application

Study Arms (2)

Control

Participants without inflammatory skin disease

Behavioral: Mental health

Patients with HS

Patients with HS

Behavioral: Mental health

Interventions

Mental health BEHAVIORAL

Early life exposure to abuse and development of hidradenitis suppurativa

Control; Patients with HS

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Hidradenitis suppurativa is an autoinflammatory skin disorder.They are difficult-to-heal and often scar. Hidradenitis suppurativa also has a significant psychological impact, and many patients suffer depression, anxiety, and impaired body-image. A hallmark of hidradenitis suppurativa is increased levels of biomarkers, which are molecules found in blood, other body fluids, or tissues that can be a sign of a normal or abnormal process. In hidradenitis suppurativa, these biomarkers are called "cytokines" and their job is to trigger the disease and make it worse.

You may qualify if:

• Diagnosed with hidradenitis suppurativa
• Not Pregnant

You may not qualify if:

• Mild/general dermatological issues like moles, other cosmetic issues
• Patients with hidradenitis suppurativa, psoriasis, roasacea, atopic dermatitis and other inflammatory skin disease
• Pregnant

Sponsors & Collaborators

• University of Alabama at Birmingham: lead

Study Sites (1)

Whitaker Clinic

Birmingham, Alabama, 35294, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Hidradenitis Suppurativa

Interventions

Mental Health

Condition Hierarchy (Ancestors)

Skin Diseases, Bacterial; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Skin Diseases, Infectious; Suppuration; Skin Diseases; Skin and Connective Tissue Diseases; Hidradenitis; Sweat Gland Diseases

Intervention Hierarchy (Ancestors)

Health; Population Characteristics

Study Officials

• Nabiha Yusuf

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nabiha Yusuf

CONTACT

2059347432; nabihayusuf@uabmc.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 16, 2022
• First Posted: August 18, 2022
• Study Start: October 11, 2022
• Primary Completion (Estimated): August 31, 2027
• Study Completion (Estimated): August 31, 2028
• Last Updated: August 7, 2026

Record last verified: 2025-08

Locations

US (1)