Interindividual Postexercise Hypotension Response in Morbid Obesity

NCT05504629 | Completed DMC

• 1 other identifier: UNAB-FCR-KINE2022A
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

A quasi-experimental study developed in sedentary morbidly obese men and women (age 43.6±11.3 y; body mass index \[BMI\] ≥40 kg/m2) were assigned to a CT group of ET plus RT (ET+RT; n=19; BMI 47.8±16.7) or RT plus ET order group (RT+ET; n=17; BMI 43.0±8.0). Subjects of both groups received eight exercise sessions over four weeks. Systolic (SBP), diastolic (DBP), mean arterial pressure \[MAP\], heart rate at rest \[HR\], and pulse pressure \[PP\] measurements before and after 10 minutes postexercise. Secondary outcomes were other anthropometric, body composition, metabolic, and physical condition parameters. Using the ∆SBP reduction, and quartile categorization (Q) in 'high' (Rs: quartile 4), 'moderate' (MRs: quartile 3), 'low' (LRs: quartile 2), and 'nonresponders' (NRs: quartile 1) were reported.

Conditions

Metabolic Syndrome; Morbid Obesity

Outcome Measures

Primary Outcomes (3)

• Systolic blood pressure measured by a blood pressure cuff

  Change from Baseline in systolic blood pressure in the unit of (mmHg)

  From baseline to 10 minutes after exercise training

• Diastolic blood pressure measured by a blood pressure cuff

  Change from Baseline in diastolic blood pressure in the unit of (mmHg)

  From baseline to 10 minutes after exercise training

• Mean arterial pressure measured by a blood pressure cuff

  Change from Baseline in mean arterial blood pressure in the unit of (mmHg)

  From baseline to 10 minutes after exercise training

Secondary Outcomes (18)

• Heart rate at rest measured by a cardiometer watch

  From baseline to 10 minutes after exercise training

• Pulse pressure measured by a blood pressure cuff

  From baseline to 10 minutes after exercise training

• Body mass measured by a scale

  From baseline to 10 minutes after exercise training

• Body mass index calculated from weight plus height and elevated to square

  From baseline to 10 minutes after exercise training

• Waist circumference measured by a flexible tape

  From baseline to 10 minutes after exercise training

Study Arms (2)

Endurance Training (ET) plus Resistance Training (RT)

EXPERIMENTAL

Concurrent training of Endurance Training plus Resistance Training order.

Behavioral: RT+ET

Resistance Training (RT) plus Endurance Training (ET)

ACTIVE COMPARATOR

Concurrent training of Resistance Training plus Endurance Training order.

Behavioral: Concurrent training order 1

Interventions

Concurrent training order 1 BEHAVIORAL

atag

Also known as: Exercise training

Resistance Training (RT) plus Endurance Training (ET)

RT+ET BEHAVIORAL

aetaer

Also known as: Concurrent training order 2

Endurance Training (ET) plus Resistance Training (RT)

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• age \>18 and \<60 years
• women or men
• medical authorization for physical tests
• body mass index (BMI) ≥40 kg/m2, or between 35 and 40 kg/m2 but with previously diagnosed of morbid obesity and candidate for bariatric surgery

You may not qualify if:

• physical limitations to performing the physical test (e.g., restrictive injuries of the musculoskeletal system)
• exercise-related dyspnoea or respiratory alterations
• chronic heart disease diagnosed during the time of morbid obesity diagnosed and the starting of the exercise intervention

Sponsors & Collaborators

• Universidad Nacional Andres Bello: lead
• Universidad de La Frontera: collaborator

Study Sites (1)

Universidad de La Frontera

Temuco, Chile

Location

Related Publications (3)

• Delgado-Floody P, Izquierdo M, Ramirez-Velez R, Caamano-Navarrete F, Moris R, Jerez-Mayorga D, Andrade DC, Alvarez C. Effect of High-Intensity Interval Training on Body Composition, Cardiorespiratory Fitness, Blood Pressure, and Substrate Utilization During Exercise Among Prehypertensive and Hypertensive Patients With Excessive Adiposity. Front Physiol. 2020 Oct 19;11:558910. doi: 10.3389/fphys.2020.558910. eCollection 2020.

  PMID: 33192554 RESULT

• Delgado-Floody P, Soriano-Maldonado A, Rodriguez-Perez MA, Latorre-Roman PA, Martinez-Salazar C, Vargas CA, Caamano-Navarrete F, Jerez-Mayorga D, Alvarez C. The Effects of Two Different Concurrent Training Configurations on Markers of Metabolic Syndrome and Fitness in Women With Severe/Morbid Obesity: A Randomised Controlled Trial. Front Physiol. 2021 Sep 21;12:694798. doi: 10.3389/fphys.2021.694798. eCollection 2021.

  PMID: 34621181 RESULT

• Alvarez C, Ramirez-Campillo R, Ramirez-Velez R, Izquierdo M. Effects and prevalence of nonresponders after 12 weeks of high-intensity interval or resistance training in women with insulin resistance: a randomized trial. J Appl Physiol (1985). 2017 Apr 1;122(4):985-996. doi: 10.1152/japplphysiol.01037.2016. Epub 2017 Feb 2.

  PMID: 28153946 RESULT

MeSH Terms

Conditions

Metabolic Syndrome; Obesity, Morbid

Interventions

Exercise

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Obesity; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Pedro Delgado Floody, PhD

  Universidad de La Frontera

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: August 13, 2022
• First Posted: August 17, 2022
• Study Start: March 5, 2019
• Primary Completion: September 5, 2019
• Study Completion: October 5, 2019
• Last Updated: August 24, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)