To Study the Healing Effect of 0.25% Lemongrass Oil Mouthwash on Chronic Periodontitis Patients.

NCT05502627 | Completed DMC

• 1 other identifier: PGMILahorePakistan
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is the inflammation of the tissues supporting the teeth. Lemongrass (Cymbopogon Citratus) oil mouthwash can be used with subgingival scaling in the treatment of periodontal diseases. Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to transforming growth factor superfamily and its elevated levels are detectable in inflammatory and healing process The present project will be conducted to evaluate the expression of TGF-β levels in chronic periodontitis patients after ultrasonic scaling and using 0.25% lemongrass oil mouthwash. TGF-β is a salivary marker of periodontitis.

Conditions

Chronic Periodontitis

Outcome Measures

Primary Outcomes (1)

• To observe the healing of patients with chronic periodontitis.

  0.25% lemon grass oil effect on healing of chronic periodontitis by measuring levels of TGF-Beta.

  10 months

Study Arms (2)

Experimental group

scaling was done along with intervention (0.25% lemongrass mouthwash was given)

Drug: 0.25% lemon grass oil mouthwash

control group

only scaling was done

Interventions

0.25% lemon grass oil mouthwash DRUG

0.25% lemon grass oil mouth wash given twice daily for fourteen days to the patients of chronic periodontitis after scaling in experimental group and in control group only scaling was done.

Also known as: lemon grass mouth wash

Experimental group

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Male or female with age range between 40-60 years with generalized periodontitis were taken for the study

You may qualify if:

• Male or female of age between 40-60 years with generalized periodontitis
• Minimum 15 teeth should present in oral cavity
• Patient who don't have received periodontal therapy for last three months
• Probing depth \> 3mm

You may not qualify if:

• Patient taking antibiotics or NSAIDS within last three months
• Patients with oral mucous lesions, Oral carcinoma, xerostomia, previous history of radiotherapy or chemotherapy
• Hypersensitivity to lemongrass
• Any systemic illness
• Pregnant females

Sponsors & Collaborators

• Postgraduate Medical Institute, Lahore: lead

Study Sites (1)

Punjab dental hospital

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Asrar Ahmed, M. Phil. OB

  PGMI, Lahore

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 11, 2022
• First Posted: August 16, 2022
• Study Start: April 1, 2021
• Primary Completion: January 1, 2022
• Study Completion: April 20, 2022
• Last Updated: August 16, 2022

Record last verified: 2022-08

Locations

PA (1)