Project RESIST: Evaluating the Effects of Anti-smoking Inoculation Messages Among Young Adult Sexual Minority Women

NCT05499520 | Completed Results

• 2 other identifiers: 11022R01CA237670
• Study Type: interventional
• Target: 2,591
• Locations: 1 country
• Sites: 1

Brief Summary

Project RESIST is an R01 study funded by NCI focused on determining the effects of using culturally tailored inoculation approaches to increase resilience to tobacco marketing influences among young adult sexual minority women ages 18-30 and incorporates critical stakeholder inputs that support later adoption and implementation. The study team is utilizing formative research to design and pre-test anti-smoking messages and two national longitudinal online survey experiments.

Conditions

Cigarette Smoking Behavior

Outcome Measures

Primary Outcomes (3)

• Intention to Quit Smoking at Follow-up

  We used a 4-item scale on intention to quit smoking at baseline and at follow-up (immediate, one-week and one-month) among current smokers only: 1. I will make an effort to quit smoking in the next 30 days; 2. I intend to quit smoking in the next 30 days; 3. I expect to quit smoking in the next 30 days; 4. How likely is it that you will quit smoking in the next 30 days. Responses ranged on 7-point Likert-like scales. Responses were summed to create a scale for intention to quit (range from 4-28), higher scores indicate higher intention to quit.

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

• Intention to Purchase Cigarettes

  The Juster scale was used to measure intention to purchase cigarettes at baseline and at one-month follow-up. Participants were asked, "How likely are you to purchase cigarettes in the next 6 months?" Responses ranged from 0=No chance, almost no chance (1 in 100) to 10=Certain, practically certain (99 in 100). Higher values reflect higher intention to purchase.

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

• Susceptibility to Smoke Cigarettes

  Susceptibility to smoke cigarettes were measured using four-items: 1. Have you ever been curious about smoking a cigarette? 2. Do you think you will smoke a cigarette in the next year? 3. Do you think that you will try a cigarette soon? 4. If one of your best friends were to offer you a cigarette, would you smoke it? Responses ranged on 4-point Likert-like scales. Responses were summed to create a scale for susceptibility to smoke cigarettes (range from 0-12). This was only measured among participants who did not currently smoke. Higher scores indicate increased susceptibility to smoke cigarettes.

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

Secondary Outcomes (3)

• Receptivity to Marketing

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

• Tobacco Industry Attitudes

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

• Tobacco Industry Beliefs

  Day [0] reported for No-message, single-message immediate, & 3-messages immediate conditions; Week [1] reported for Single-message & 3-messages 1-week delay conditions; Month [1] reported for Single-message & 3-messages 1-month delay conditions

Study Arms (18)

Currently Smoking, No Message Condition

NO INTERVENTION

Participants will receive no anti-smoking messages. They will receive the threat message during the baseline survey. Outcomes will be measured before and immediately after seeing the threat message, and at 1 month.

Currently Smoking, Single Message Immediate

EXPERIMENTAL

Participants will receive a single anti-smoking message followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking message and threat message, immediately after seeing the threat message, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Single Message 1 Week Delay

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, immediately after seeing the threat message at 1 week, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Single Message 1 Month Delay

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Single Message 1 Month Delay, Repeated Exposure

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of a single anti-smoking message at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking message at baseline and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Three Messages Immediate

EXPERIMENTAL

Participants will receive three anti-smoking messages, followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking messages and threat message, immediately after seeing the threat message, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Three Messages 1 Week Delay

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, immediately after seeing the threat message at 1 week, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Three Messages 1 Month Delay

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Currently Smoking, Three Messages 1 Month Delay Repeat Exposure

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of three anti-smoking messages at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking messages at baseline and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, No Message Condition

NO INTERVENTION

Participants will receive no anti-smoking messages. They will receive the threat message during the baseline survey. Outcomes will be measured before and immediately after seeing the threat message, and at 1 month.

Not Currently Smoking, Single Message Immediate

EXPERIMENTAL

Participants will receive a single anti-smoking message followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking message and threat message, immediately after seeing the threat message, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Single Message 1 Week Delay

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, immediately after seeing the threat message at 1 week, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Single Message 1 Month Delay

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking message at baseline, and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Single Message 1 Month Delay, Repeated Exposure

EXPERIMENTAL

Participants will receive a single anti-smoking message during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of a single anti-smoking message at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking message at baseline and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Three Messages Immediate

EXPERIMENTAL

Participants will receive three anti-smoking messages, followed by the threat message during the baseline survey. Outcomes will be measured before seeing the anti-smoking messages and threat message, immediately after seeing the threat message, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Three Messages 1 Week Delay

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one week later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, immediately after seeing the threat message at 1 week, and at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Three Messages 1 Month Delay

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later in a separate survey. Outcomes will be measured before seeing the anti-smoking messages at baseline, and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Not Currently Smoking, Three Messages 1 Month Delay Repeat Exposure

EXPERIMENTAL

Participants will receive three anti-smoking messages during the baseline survey, followed by the threat message one month later. Participants will also receive repeated exposures of three anti-smoking messages at 1, 2, and 3 weeks in separate surveys. Outcomes will be measured before seeing the anti-smoking messages at baseline and immediately after seeing the threat message at 1 month.

Other: Culturally Tailored Anti-Smoking Messages

Interventions

Culturally Tailored Anti-Smoking Messages OTHER

Anti-smoking messages will be administered online via a Qualtrics survey.

Currently Smoking, Single Message 1 Month Delay; Currently Smoking, Single Message 1 Month Delay, Repeated Exposure; Currently Smoking, Single Message 1 Week Delay; Currently Smoking, Single Message Immediate; Currently Smoking, Three Messages 1 Month Delay; Currently Smoking, Three Messages 1 Month Delay Repeat Exposure; Currently Smoking, Three Messages 1 Week Delay; Currently Smoking, Three Messages Immediate; Not Currently Smoking, Single Message 1 Month Delay; Not Currently Smoking, Single Message 1 Month Delay, Repeated Exposure; Not Currently Smoking, Single Message 1 Week Delay; Not Currently Smoking, Single Message Immediate; Not Currently Smoking, Three Messages 1 Month Delay; Not Currently Smoking, Three Messages 1 Month Delay Repeat Exposure; Not Currently Smoking, Three Messages 1 Week Delay; Not Currently Smoking, Three Messages Immediate

Eligibility Criteria

• Age: 18 Years - 30 Years
• Gender Eligibility Details: Anyone who identifies as a woman, whether they are cisgender or transgender, would meet the gender-based eligibility requirement
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Ages 18-30
• Woman
• Identifies as a sexual minority (any sexual orientation other than heterosexual)
• Lives in the United States
• Able to take surveys in English

You may not qualify if:

• Under 18 or older than 30
• Men
• Heterosexual
• Lives outside the United States
• Unable to take the survey in English

Sponsors & Collaborators

• Abramson Cancer Center at Penn Medicine: lead
• National Cancer Institute (NCI): collaborator
• Harvard School of Public Health (HSPH): collaborator
• Stanford University: collaborator
• Dana-Farber Cancer Institute: collaborator
• Fenway Community Health: collaborator

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

Cigarette Smoking

Condition Hierarchy (Ancestors)

Tobacco Smoking; Smoking; Behavior; Tobacco Use

Results Point of Contact

• Title: Andy Tan
• Organization: University of Pennsylvania

andy.tan@asc.upenn.edu

2157466546

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 4, 2022
• First Posted: August 12, 2022
• Study Start: September 21, 2022
• Primary Completion: July 5, 2023
• Study Completion: August 15, 2023
• Last Updated: July 31, 2024
• Results First Posted: July 31, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)