The Effect of Gallstone Characteristics for the Severity of Gallstone Pancreatitis

NCT05498961 | Completed

• 1 other identifier: acute gallstone pancreatitis
• Study Type: observational
• Target: 301
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to determine the effect of gallstone characteristics for the severity of acute gallstone pancreatitis (GSP)

Conditions

Acute Gallstone Pancreatitis

Keywords

Pancreatitis; Gallstone; Severity

Outcome Measures

Primary Outcomes (1)

• Number of severity of GSP patients

  Based on the 2012 Atlanta International Consensus, Mild acute pancreatitis (MAP) is defined as no organ failure and no local or systemic complications. Moderate to severe acute pancreatitis (MSAP) refers to patients with organ failure, local complications, or aggravated complications. Severe acute pancreatitis (SAP) is defined as persistent organ failure for more than 48 hours.

  1 month

Secondary Outcomes (3)

• Modified computed tomography severity index (MCTSI) score

  1 month

• Gallstone size

  1 month

• Number of stones

  1 month

Interventions

Gallstone characteristics OTHER

stone size, number, the thickness

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Acute gallstone pancreatitis patients

You may qualify if:

• Acute gallstone pancreatitis (GSP) patients.

You may not qualify if:

• Pancreatitis with bile duct stones, trauma, drugs, and surgery;
• Recurrent gallstone pancreatitis;
• Combined with other malignant tumors, such as liver cancer, cholangiocarcinoma, pancreatic cancer, gastric cancer, Hematologic tumor, and lymphoma;
• Previous hepatobiliary and pancreatic surgery, Organ transplantation;
• Intestinal obstruction or other obstructive diseases;
• Chronic pancreatitis or pancreatic duct stones;
• Thrombotic disease;
• Alcoholic pancreatitis and hyperlipidemia pancreatitis.

Sponsors & Collaborators

• Hepatopancreatobiliary Surgery Institute of Gansu Province: lead

Study Sites (1)

Hepatopancreatobiliary Surgery Institute of Gansu Province

Lanzhou, Gansu, 730000, China

Location

Related Publications (3)

• Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun;144(6):1252-61. doi: 10.1053/j.gastro.2013.01.068.

  PMID: 23622135 BACKGROUND

• Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, van Santvoort HC, Besselink MG. Acute pancreatitis. Lancet. 2020 Sep 5;396(10252):726-734. doi: 10.1016/S0140-6736(20)31310-6.

  PMID: 32891214 BACKGROUND

• Ma Y, Yue P, Zhang J, Yuan J, Liu Z, Chen Z, Zhang H, Zhang C, Zhang Y, Dong C, Lin Y, Liu Y, Li S, Meng W. Early prediction of acute gallstone pancreatitis severity: a novel machine learning model based on CT features and open access online prediction platform. Ann Med. 2024 Dec;56(1):2357354. doi: 10.1080/07853890.2024.2357354. Epub 2024 May 30.

  PMID: 38813815 DERIVED

MeSH Terms

Conditions

Pancreatitis; Gallstones

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases; Cholelithiasis; Biliary Tract Diseases; Cholecystolithiasis; Gallbladder Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Wenbo Meng, M.D.,Ph.D

  LanZhou University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of surgery

Study Record Dates

• First Submitted: August 10, 2022
• First Posted: August 12, 2022
• Study Start: August 10, 2022
• Primary Completion: September 24, 2023
• Study Completion: September 24, 2023
• Last Updated: September 26, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)