Computational Prediction and Experimental Validation of Gastric Cancer Associated Neoantigens
1 other identifier
observational
50
1 country
1
Brief Summary
This study is to develop methods for identification of neoantigens from patients with gastric cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 9, 2022
CompletedFirst Posted
Study publicly available on registry
August 11, 2022
CompletedStudy Start
First participant enrolled
August 15, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedAugust 11, 2022
August 1, 2022
1.4 years
August 9, 2022
August 9, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
The neoantigen landscape of patients with gastric cancer
The analysis of tumor DNA and RNA sequencing data will provide the mutational distribution of patients with gastric cancer, which could give rise to neoantigens. Of those, neoantigens derived from hotspot mutations in Vietnamese gastric cancer patients will be identified.
3 months from the beginning of the study
Secondary Outcomes (2)
The ratio of predicted neoantigens being presented by HLA-I
6 months from the beginning of the study
The ratio of predicted neoantigens being immunogenic.
12 months from the beginning of the study
Interventions
10 ml of whole blood is collected from each patient prior surgery Fresh tumor tissue samples (\~ 1cm3 ) are collected during surgery
Eligibility Criteria
All the patients who were diagnosed with adavanced gastric cancer and underwent surgical resection
You may qualify if:
- Male or Female patients aged 15 years and older
- Diagnosed with advanced gastric cancer (T2-4b/N0-3/M0-1 stage, according to the eighth edition of the American Joint Committee on Cancer TNM (AJCC TNM) system)
- Treatment-Naive
- Not known for other concomitant cancers
- Provide written informed consent
You may not qualify if:
- Insufficient tumor tissues (less than 1 cm3)
- Unable to sign informed consent
- Underwent treatment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Medical Center Ho Chi Minh City
Ho Chi Minh City, 700000, Vietnam
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 9, 2022
First Posted
August 11, 2022
Study Start
August 15, 2022
Primary Completion
December 31, 2023
Study Completion
December 31, 2023
Last Updated
August 11, 2022
Record last verified: 2022-08
Data Sharing
- IPD Sharing
- Will not share