NCT05496530

Brief Summary

Suprachoroidal drug delivery is a recent route for managing various ocular conditions. Safety and long term results are still under investigations.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2022

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 10, 2022

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

August 9, 2022

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 11, 2022

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2023

Completed
16 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 15, 2023

Completed
Last Updated

August 11, 2022

Status Verified

August 1, 2022

Enrollment Period

1.1 years

First QC Date

August 9, 2022

Last Update Submit

August 9, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Visual acuity

    Changes noted in vision after injection measured 8n logMar units by snellen chart.

    Baseline and up to one year after injection.

Secondary Outcomes (1)

  • Central macular thickness

    Baseline and up to one year after injection.

Other Outcomes (1)

  • Intraocular pressure

    Baseline and up to one year after injection.

Study Arms (3)

Diabetic macular edema

ACTIVE COMPARATOR

Cases with diabetic macular edema with central macular thickness more than 300 microns measured by optical coherence tomography.

Drug: Suprachoroidal triamcinolone acetonide injection

Vogt-koyanagi harada

ACTIVE COMPARATOR

Cases with vogt-koyanagi harada and complicated with exudative retinal detachment confirmed by optical coherence tomography.

Drug: Suprachoroidal triamcinolone acetonide injection

Retinal vein occlusion

ACTIVE COMPARATOR

Cases with retinal vein occlusion and complicated with macular edema confirmed by optical coherence tomography.

Drug: Suprachoroidal triamcinolone acetonide injection

Interventions

Pars plana suprachoroidal injection of 4mg//0.1ml triamcinolone acetonide.

Diabetic macular edemaRetinal vein occlusionVogt-koyanagi harada

Eligibility Criteria

Age30 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • cases with central macular thickness more than 250 microns measured by optical coherence tomography due to one of the following conditions:
  • Diabetic macular edema
  • Vogt-koyanagi Harada disease
  • Retinal vein occlusion.

You may not qualify if:

  • other causes of increased macular thickness as age related macular degeneration and myopic choroidal new vascularization.
  • Cases with confirmed diagnosis of glaucoma.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ahmed Abdelshafy Tabl

Banhā, Benha, 13511, Egypt

RECRUITING

MeSH Terms

Conditions

Uveomeningoencephalitic SyndromeRetinal Vein Occlusion

Condition Hierarchy (Ancestors)

Autoimmune Diseases of the Nervous SystemNervous System DiseasesUveitisUveal DiseasesEye DiseasesAutoimmune DiseasesImmune System DiseasesRetinal DiseasesVenous ThrombosisThrombosisEmbolism and ThrombosisVascular DiseasesCardiovascular Diseases

Study Officials

  • Ahmed A Tabl

    Benha University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer of Ophthalmology

Study Record Dates

First Submitted

August 9, 2022

First Posted

August 11, 2022

Study Start

July 10, 2022

Primary Completion

July 30, 2023

Study Completion

August 15, 2023

Last Updated

August 11, 2022

Record last verified: 2022-08

Locations