Antibodies and Immunity After Vaccination of Recovered Patients With COVID-19 and Long COVID-19 Symptoms

NCT05484700 | Unknown

• 1 other identifier: 1013/2564(IRB3)
• Study Type: observational
• Target: 305
• Locations: 1 country
• Sites: 1

Brief Summary

We investigated the association between immune system responsibilities in Long COVID patients and Full recovery patients.

Conditions

Long COVID-19

Keywords

Long COVID-19; antibody responsibility; immunogenicity

Outcome Measures

Primary Outcomes (3)

• Anti-SARS-CoV-2 RBD IgG

  anti-SARS-CoV-2 receptor-binding domain immunoglobulin G(BAU/mL)

  Baseline

• Anti-SARS-CoV-2 NP

  surrogate Virus Neutralization Test (sVNT) (PRNT50 titer)

  Baseline

• Microneutralization assays

  Microneutralization assays using the authentic SARS-CoV-2 viruses

  Baseline

Secondary Outcomes (2)

• Number of vaccine injection

  Baseline

• Prevalence of Long COVID-19 symptoms

  Baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The COVID-19 patients who confirmed SARS-CoV-2 infection from January to May 2022 (during the Omicron wave), and post COVID-19 they had not received any additional COVID vaccine.

You may qualify if:

• Long COVID group; at longer than 1-month post COVID-19 based the presence of one of the three following symptoms: fatigue/myalgia, breathlessness, and anorexia
• Full recovery group; patients with asymptomatic symptoms
• post COVID-19 they had not received any additional COVID vaccine

You may not qualify if:

• people who received additional vaccination after leaving quarantine before the day of the immunization test
• pregnant patients,
• people who had a history of allergic reactions after COVID-19 vaccination or any drugs

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, 10700, Thailand

Location

Biospecimen

Retention: SAMPLES WITH DNA

Plasma Serum

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Korapat Mayurasakorn, MD.

  Doctor in Family Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2022
• First Posted: August 2, 2022
• Study Start: December 30, 2021
• Primary Completion: July 25, 2022
• Study Completion: December 29, 2022
• Last Updated: August 5, 2022

Record last verified: 2022-08

Locations

TH (1)