Platelet Rich Plasma Testis Treatment for Infertile Men

NCT05479474 | Recruiting

• 1 other identifier: 65917
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval. Currently, there is no alternative treatment after failed TESE. Prior series suggest that intratesticular PRP injections may improve TESE outcomes. We hope to determine whether PRP is an effective treatment for this patient population.

Conditions

Male Infertility; Nonobstructive Azoospermia; Azoospermia

Outcome Measures

Primary Outcomes (1)

• sperm present

  A TESE procedure will be performed to determine if sperm are present

  3 months after PRP injection

Study Arms (1)

Platelet rich plasma treatment arm

EXPERIMENTAL

After consent in obtained, the patient will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle.

Biological: Platelet rich plasma

Interventions

Platelet rich plasma BIOLOGICAL

Patients will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle. * On the third month after the testicular PRP procedure, a TESE will be performed * If the procedure is successful a new IVF cycle using the sperm procured from the procedure will be done.

Platelet rich plasma treatment arm

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men over the age of 18 diagnosed with NOA and at least one failed TESE, negative mapping or negative biopsy

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford Urology Clinic

Stanford, California, 94304, United States

RECRUITING

MeSH Terms

Conditions

Infertility, Male; Azoospermia, Nonobstructive; Azoospermia

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Central Study Contacts

Satvir Basran

CONTACT

650-723-0948; sbasran@stanford.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 21, 2022
• First Posted: July 29, 2022
• Study Start: January 18, 2023
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

US (1)