A Global Approach to Tackle Cognitive Decline

NCT05479318 | Active Not Recruiting DMC

• 1 other identifier: 2022.119
• Study Type: observational
• Target: 1,502
• Locations: 1 country
• Sites: 1

Brief Summary

The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.

Conditions

Dementia

Outcome Measures

Primary Outcomes (12)

• Record of any vascular risk factors

  medical history of hypertension, diabetes mellitus, hyperlipidemia, smoking and drinking, record unit as yes or no

  Baseline

• Record of triglyceride level

  triglyceride level, as one of vascular risk factors, unit as mmol/L

  Baseline

• Record of high-density-lipoprotein level,

  high-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L

  Baseline

• Record of low-density-lipoprotein level,

  low-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L

  Baseline

• Record of total cholesterol level,

  total cholesterol level, as one of the vascular risk factors, unit as mmol/L

  Baseline

• Record of glycated hemoglobin

  glycated hemoglobin, as one of the vascular risk factors, unit as percentage

  Baseline

• Record of fasting blood glucose

  fasting blood glucose from blood results, as one of vascular risk factors, unit as mmol/L

  Baseline

• Record of blood pressure

  Blood pressure, as one of vascular risk factors, unit as mmHg

  Baseline

• Record of pulse

  Pulse rate, as one of vascular risk factors, unit as bpm

  Baseline

• Change of Mini-Mental State Examination

  Mini-Mental State Examination is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.

  Baseline and 3rd year follow up

• Change of Montreal Cognitive Assessment

  Montreal Cognitive Assessment is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.

  Baseline, 1 yr, 2yr and 3rd year follow ups

• Changes of brain white matter abnormalities

  brain white matter abnormalities can be observed through the FLAIR sequence of brain MRI images

  Baseline and 1 yr, 2yr and 3rd year follow ups

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be retrospectively selected from 7 cohorts from Hong Kong, Australia, Singapore and Europe areas.

You may qualify if:

• Elderly community-dwelling individuals aged over 60 years old;
• those with at least 2 time points of detailed cognitive measurements, with 2-3 years of assessment interval;
• with at least 1 timepoint of MRI (T1, FLAIR, and DTI).

You may not qualify if:

• subjects with stroke, dementia, and other neurological diseases at baseline;
• those without longitudinal cognitive data;
• those without MRI data available.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead
• The University of New South Wales: collaborator
• University of Oxford: collaborator
• University College, London: collaborator
• Umeå University: collaborator
• Max Planck Institute for Human Development: collaborator
• National University of Singapore: collaborator

Study Sites (1)

Prince of Wales Hospital

Shatin, N.T., 00000, Hong Kong

Location

MeSH Terms

Conditions

Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Bonnie Yin Ka Lam

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant Professor

Study Record Dates

• First Submitted: May 18, 2022
• First Posted: July 29, 2022
• Study Start: September 1, 2022
• Primary Completion: May 1, 2025
• Study Completion: October 1, 2025
• Last Updated: February 15, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)