NCT05476081

Brief Summary

The REAl-life study on short-term Dual Antiplatelet treatment in Patients with ischemic stroke or Transient ischemic attack (READAPT) is an observational, multicenter, prospective study involving Italian centers. The study aims at evaluating effectiveness and safety of short-term (21-90 days) dual antiplatelet treatment (DAPT) in secondary prevention of mild-to-moderate ischemic stroke or high-risk TIA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,239

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2021

Typical duration for all trials

Geographic Reach
1 country

127 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 3, 2021

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

July 24, 2022

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 27, 2022

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 3, 2023

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 3, 2023

Completed
Last Updated

December 5, 2024

Status Verified

December 1, 2024

Enrollment Period

2 years

First QC Date

July 24, 2022

Last Update Submit

December 4, 2024

Conditions

Keywords

DAPTStrokeTIAantiplatelet treatment

Outcome Measures

Primary Outcomes (1)

  • Primary composite outcome

    Death, stroke recurrence (ischemic or hemorrhagic)

    90 days from DAPT start

Secondary Outcomes (12)

  • Ischemic stroke

    90 days from DAPT start

  • TIA

    90 days from DAPT start

  • Intracerebral hemorrhage (ICH)

    90 days from DAPT start

  • Subarachnoid hemorrhage

    90 days from DAPT start

  • Other intracranial hemorrhage

    90 days from DAPT start

  • +7 more secondary outcomes

Other Outcomes (2)

  • Modified Rankin Scale (mRs)

    90 days from DAPT start

  • Early DAPT discontinuation

    90 days from DAPT start

Study Arms (1)

Patients (single cohort study)

Patients presenting with a mild-to-moderate ischemic stroke or high risk TIA

Drug: AspirinDrug: ClopidogrelDrug: Ticagrelor

Interventions

Aspirin (100-300 mg) administered for 21-90 days in combination with another antiplatelet treatment

Also known as: B01AC06, acetylsalicylic acid
Patients (single cohort study)

Clopidogrel (75-600 mg) administered for 21-90 days in combination with another antiplatelet treatment

Also known as: B01AC04
Patients (single cohort study)

Ticagrelor (90-180 mg) administered for 21-90 days in combination with another antiplatelet treatment

Also known as: B01AC24
Patients (single cohort study)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with a mild-to-moderate ischemic stroke or high risk TIA (according to the NIHSS Stroke scale and ABCD2 score respectively) receiving 21/90-day DAPT as secondary prevention according to clinical practice. No cutoffs of NIHSS score or ABCD2 score have been established, but we recommend to follow international guidelines.

You may qualify if:

  • Patients with mild or moderate non-cardioembolic ischemic stroke or high-risk TIA treated with a short course of DAPT (usually 21-30 days but up to 90-day at the physician's discretion) for the acute event;
  • Male or female aged \>18 years;
  • Providing signed and dated informed consent;
  • Willing to comply with all study procedures and to be available for the duration of the study.

You may not qualify if:

  • Patients receiving DAPT after endovascular procedures with stenting;
  • Patients participating to any interventional RCT on stroke prevention;
  • Presence of any condition which may preclude reliability of the collected information

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (127)

Neurology e Stroke Unit Departement, SS Filippo e Nicola Hospital

Avezzano, Abruzzo, 67051, Italy

Location

Department of Neurology and Stroke Unit, Ente Ecclesiastico ospedale Generale Regionale Miulli

Acquaviva delle Fonti, Italy

Location

Department f Neurology, AO Nazionale SS Biagio and Cesare Arrigo

Alessandria, Italy

Location

Department of Neurology, Murgia Hospital Fabio Perinei SS 96

Altamura, Italy

Location

Department of Neurology and Stroke Unit Ospedali Riuniti Ancona

Ancona, Italy

Location

Department of Neurology, INRCA-IRCCS "U Sestili" Hospital

Ancona, Italy

Location

Department of Neurology and Stroke Unit, "U. Parini" Hospital

Aosta, Italy

Location

Department of Neurology, San Donato Hospital, Azienda USL Toscana Sud Est, Arezzo e Val D'Arno

Arezzo, Italy

Location

Department of Neurology and Stroke Unit, "Di Venere" Hospital

Bari, Italy

Location

Stroke Unit, Policlinico di Bari, Giovanni XXIII Hospital

Bari, Italy

Location

Department of Neurology and Stroke Unit, "Mons. Dimiccoli" Hospital

Barletta, Italy

Location

Department of Neurology,San Bassiano Hospital

Bassano del Grappa, Italy

Location

Stroke Unit, San Martino di Belluno Hospital ULSS 1

Belluno, Italy

Location

Department of Neurology, AO San Pio

Benevento, Italy

Location

Department of Neurology and Stroke Unit, Maggiore Hospital, IRCCS Istituto delle Scienze Neurologiche di Bologna

Bologna, Italy

Location

Department of Neurology, Policlinico S. Orsola-Malpighi-Clinica Neurologica Metropolitana, IRCCS Istituto delle Scienze Neurologiche di Bologna

Bologna, Italy

Location

Stroke Center, Gubbio-Gualdo Tadino Hospital

Branca, Italy

Location

Neuro-vascular Unit, AO Spedali Civili

Brescia, Italy

Location

Stroke Unit, ASST Franciacorta

Brescia, Italy

Location

Stroke Unit, Istituto Ospedaliero Fondazione Poliambulanza

Brescia, Italy

Location

Stroke Unit, A. Perrino Hospital

Brindisi, Italy

Location

Department of Neurology and Stroke Unit, AO "G. Brotzu"

Cagliari, Italy

Location

Department of Neurology and Stroke Unit, S Elia Hospital

Caltanissetta, Italy

Location

Stroke Unit, AO San Sebastiano AORN Caserta

Caserta, Italy

Location

Department of Neurology, San Giacomo Hospital

Castelfranco Veneto, Italy

Location

Department of Neurology, AO Cannizzaro

Catania, Italy

Location

Department of Neurology, Institute G. Giglio di Cefalù

Cefalù, Italy

Location

Department of Neurology and Stroke Unit, "Bufalini" Hospital

Cesena, Italy

Location

Department of Neurology and Stroke Unit, SS Annunziata Hospital

Chieti, Italy

Location

Department of Neurology and Stroke Unit, Cittadella, AULSS6 Euganea

Cittadella, Italy

Location

Stroke Center, USL umbria 1

Città di Castello, Italy

Location

Stroke Unit, Valduce Hospital

Como, Italy

Location

Department of Neurology, Conegliano Hospital Aulss 2 Veneto

Conegliano, Italy

Location

Department of Neurology and Stroke Unit, ASST Maggiore Hospital of Crema

Crema, Italy

Location

Department of Neurology, ASST Cremona

Cremona, Italy

Location

Department of Neurology, Santa Croce Hospital

Cuneo, Italy

Location

Department of Neurology and Stroke Unit, Desio Hospital ASST Monza

Desio, Italy

Location

Department of Neurology, ASUR Area Vasta 4 (ex ZT11)

Fermo, Italy

Location

Department of NeurologY, AOU of Ferrara

Ferrara, Italy

Location

Department of Neurology, San Giovanni di Dio Hospital

Florence, Italy

Location

Stroke Unit, AOU Careggi

Florence, Italy

Location

Department of Neurology, Ente Ospedali Galliera Genova

Genova, Italy

Location

Stroke Unit, San Martino Hospital of Genova

Genova, Italy

Location

Department of Neurology, ASUGI

Gorizia, Italy

Location

Department of Neurology, USL Toscana sud est

Grosseto, Italy

Location

Department of Neurology and Stroke Unit, ASUR Marche AV2 Jesi

Iesi, Italy

Location

Department of Neuology, Sant'Andrea Hospital, Azienda Sanitaria Locale n. 5 "Spezzino" La Spezia

La Spezia, Italy

Location

Department of Neurology, F Renzetti Hospital

Lanciano, Italy

Location

UTN, Santa Maria Goretti Hospital

Latina, Italy

Location

Department of Neurology, Ospedale Vito Fazi

Lecce, Italy

Location

Department of Neurology, Legnago Hospital

Legnago, Italy

Location

Department of Neurology and Stroke Unit Ospedale of Legnano

Legnano, Italy

Location

Emergency Department, Azienda USL 6 Livorno

Livorno, Italy

Location

Department of Neurology, Valle del Serchio Hospital

Lucca, Italy

Location

Departement of Neurology, San Salvatore Hospital

L’Aquila, Italy

Location

Department of Neurology, Apuane Hospital, Azienda USL Toscana Nord Ovest

Massa, Italy

Location

Department of Neurology, ASST Melegnano e della Martesana

Melegnano, Italy

Location

Department of Neurology, ASST Merate

Merate, Italy

Location

Stroke Unit, AOU Gaetano Martino

Messina, Italy

Location

Stroke Unit, Angelo's Hospital

Mestre, Italy

Location

Stroke Unit, Istituto Clinico Città Studi

Milan, Italy

Location

Department of Neurology and Stroke Unit, Humanitas

Milan, Italy

Location

Department of Neurology and Stroke Unit, IRCCS Istituto Auxologico Italiano, San Luca Hospital

Milan, Italy

Location

Department of Neurology, Mirano ULSS 3 Serenissima

Mirano, Italy

Location

Stroke Unit, "S.Agostino-Estense" Hospital, AOU of Modena

Modena, Italy

Location

Stroke Unit, Santa Croce Hospital

Moncalieri, Italy

Location

Department of Neurology, San Gerardo Hospital and Bicocca University

Monza, Italy

Location

Department of Neurology and Stroke Unit, Cardarelli Hospital

Napoli, Italy

Location

Stroke Unit, Ospedale del Mare

Napoli, Italy

Location

Department of Neurology and Stroke Unit, AOU Maggiore della Carità

Novara, Italy

Location

Stroke Unit, San Giacomo Hospital

Novi Ligure, Italy

Location

Stroke Unit, AOU San Luigi Gonzaga

Orbassano, Italy

Location

Stroke Unit, Azienda Ospedale Università

Padua, Italy

Location

Department of Neurology and Stroke Unit, ARNAS Civico of Palermo

Palermo, Italy

Location

Department of Neurology, Villa Sofia Hospital

Palermo, Italy

Location

Department of Neurophysiopathology and Stroke Unit, AOUP Paolo Giaccone

Palermo, Italy

Location

Stroke Unit, Buccheri La Ferla Hospital

Palermo, Italy

Location

Department of neurology, Azienda Ospedaliero-Universitario di Parma

Parma, Italy

Location

Stroke Unit, Fidenza AUSL PR

Parma, Italy

Location

Cerebrovascula disease and Stroke Unit neurological Intitute IRCCS Mondino

Pavia, Italy

Location

Stroke Unit, AOUUD Santa Maria della Misericordia

Perugia, Italy

Location

Department of Neurology ande Stroke Unit, Pescara Hospital

Pescara, Italy

Location

Stroke Unit, Pederzoli Hospital

Peschiera del Garda, Italy

Location

Department of Neurology, AUSL Piacenza

Piacenza, Italy

Location

Departement of Neurology and Stroke Center, S.Corona Hospital

Pietra Ligure, Italy

Location

Department of Neurology and Stroke Unit, E. Agnelli Hospital

Pinerolo, Italy

Location

Department of Neurology, Azienda ospedaliera e universitaria Pisana

Pisa, Italy

Location

Department of Neurology, San Jacopo Hospital

Pistoia, Italy

Location

Stroke Unit, AO"San Carlo"

Potenza, Italy

Location

Department of Neurology, Maria Paternò Arezzo Hospital

Ragusa, Italy

Location

Department of Neurology and Stroke Unit, Santa Maria delle Croci Hospital

Ravenna, Italy

Location

Stroke Unit, AO "Bianchi-Melacrino-Morelli"

Reggio Calabria, Italy

Location

Department of Neurology and Stroke Unit, Arcispedale Santa Maria Nuova

Reggio Emilia, Italy

Location

Department of Neurology, Infermi di Rimini Hospital

Rimini, Italy

Location

Unità di trattamento neurovascolare, Azienda Ospedaliero Universitaria Policlinico Umberto I

Roma, Italy

Location

Department of Neurology and Stroke Unit, Sant'Eugenio Hospital

Rome, Italy

Location

Department of Neurology and Stroke Unit, Systems Medicin, Policlinico Tor Vergata

Rome, Italy

Location

Department of Neurology, Ospedale Fatebenefratelli

Rome, Italy

Location

Department of Neurology, Policlinico Gemelli

Rome, Italy

Location

Department of Neurology, SS Filippo Neri Hospital

Rome, Italy

Location

Stroke Unit, AO San Camillo

Rome, Italy

Location

Stroke Unit, AOU Sant'Andrea

Rome, Italy

Location

Stroke Unit, Ospedale Rovigo, ULSS 18

Rovigo, Italy

Location

Department of Neurology, Presidio ospedaliero Umberto I Nocera Inferiore

Salerno, Italy

Location

Department of Neurology, Madonna del Soccorso Hospital

San Benedetto del Tronto, Italy

Location

Department of Neurology, ASST Lariana, Sant'Anna Hospital

San Fermo della Battaglia, Italy

Location

Department of Neurology, Casa sollievo della sofferenza

San Giovanni Rotondo, Italy

Location

Stroke Unit, AOU

Sassari, Italy

Location

Department of Neurology, SS. Annunziata Hospital

Savigliano, Italy

Location

Stroke Unit, Azienda ospedaliera universitaria Senese

Siena, Italy

Location

Department of Neurology, SS Annunziata Hospital

Sulmona, Italy

Location

Department of Neurology and Stroke Unit, Umberto I Hospital

Syracuse, Italy

Location

Department of Neurology and Stroke Unit, AO Santa Maria of Terni

Terni, Italy

Location

Department of Neurology and Stroke Unit, San Giovanni Bosco Hospital

Torino, Italy

Location

Neuro-vascular Unit, Maria Vittoria Hospital

Torino, Italy

Location

Department of Neurology and Stroke Unit, ASP of Trapani

Trapani, Italy

Location

Stroke Unit, Santa Chiara Hospital

Trento, Italy

Location

Department of Neurology, Cà Foncello Hospital

Treviso, Italy

Location

Department of Neurology, Azienda Ospedaliera-Universitaria Giuliano Isontina

Trieste, Italy

Location

Department of Neurology and Rehabilitation, ASUR

Udine, Italy

Location

Department of Neurology and Stroke Unit, ASST Settelaghi

Varese, Italy

Location

Department of Neurology, SS Giovanni e Paolo Hospital, Aulss3 Serenissima Veneto

Venezia, Italy

Location

Department of Neurology, Sant'Andrea Hospital

Vercelli, Italy

Location

Department of Neurology and Stroke Unit, Arzignano Azienda ULSS 8 Berica

Vicenza, Italy

Location

Department of Neurology and Stroke Unit, San Bortolo Hospital

Vicenza, Italy

Location

Stroke Unit, ASST Vimercate

Vimercate, Italy

Location

Department of Neurology and Stroke Unit, Guzzardi Hospital

Vittoria, Italy

Location

Related Publications (9)

  • Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC; CHANCE Investigators. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013 Jul 4;369(1):11-9. doi: 10.1056/NEJMoa1215340. Epub 2013 Jun 26.

    PMID: 23803136BACKGROUND
  • Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM; FASTER Investigators. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol. 2007 Nov;6(11):961-9. doi: 10.1016/S1474-4422(07)70250-8. Epub 2007 Oct 10.

    PMID: 17931979BACKGROUND
  • Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16.

    PMID: 29766750BACKGROUND
  • Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020 Jul 16;383(3):207-217. doi: 10.1056/NEJMoa1916870.

    PMID: 32668111BACKGROUND
  • De Santis F, Ornello R, De Matteis E, D'Anna L, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Papiri G, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, De Michele M, Ricci S, Sacco S, Foschi M. Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis. Ther Adv Neurol Disord. 2025 Jul 12;18:17562864251351100. doi: 10.1177/17562864251351100. eCollection 2025.

  • De Matteis E, De Santis F, Foschi M, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Maestrini I, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zenorini M, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Paci C, Viticchi G, Orsucci D, Falcou A, Diamanti S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, Toni D, Ricci S, Sacco S, Ornello R; READAPT Study Group. Real-World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis-Insights From the READAPT Study. Eur J Neurol. 2025 Apr;32(4):e70163. doi: 10.1111/ene.70163.

  • Foschi M, D'Anna L, De Matteis E, De Santis F, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Papiri G, Paci C, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, De Michele M, Ricci S, Ornello R, Sacco S; READAPT Study Group. Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort. Stroke. 2025 Feb;56(2):305-317. doi: 10.1161/STROKEAHA.124.049210. Epub 2024 Dec 9.

  • Ornello R, Foschi M, De Santis F, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Querzani P, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Paci C, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, Toni D, Ricci S, De Matteis E, Sacco S; READAPT Study Group. Combining Intravenous Thrombolysis and Dual Antiplatelet Treatment in Patients With Minor Ischemic Stroke: A Propensity Matched Analysis of the READAPT Study Cohort. J Am Heart Assoc. 2024 Aug 20;13(16):e036275. doi: 10.1161/JAHA.124.036275. Epub 2024 Aug 9.

  • De Matteis E, De Santis F, Ornello R, Censori B, Puglisi V, Vinciguerra L, Giossi A, Di Viesti P, Inchingolo V, Fratta GM, Diomedi M, Bagnato MR, Cenciarelli S, Bedetti C, Padiglioni C, Tassinari T, Saia V, Russo A, Petruzzellis M, Mezzapesa DM, Caccamo M, Rinaldi G, Bavaro A, Paciaroni M, Mosconi MG, Foschi M, Querzani P, Muscia F, Gallo Cassarino S, Candelaresi P, De Mase A, Guarino M, Cupini LM, Sanzaro E, Zini A, La Spada S, Palmieri C, Sepe FN, Beretta S, Paci C, Caggia EA, De Angelis MV, Bonanni L, Volpi G, Tassi R, Pistoia F, Scoditti U, Tonon A, Viticchi G, Ruzza G, Nencini P, Cavallini A, Toni D, Ricci S, Sacco S; READAPT Study Group. Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke. Stroke. 2023 May;54(5):1172-1181. doi: 10.1161/STROKEAHA.122.041660. Epub 2023 Mar 23.

MeSH Terms

Conditions

Ischemic StrokeStroke

Interventions

AspirinClopidogrelTicagrelor

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

SalicylatesHydroxybenzoatesPhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsTiclopidineThienopyridinesThiophenesSulfur CompoundsPyridinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingAdenosinePurine NucleosidesPurinesNucleosidesNucleic Acids, Nucleotides, and NucleosidesRibonucleosides

Study Officials

  • Simona Sacco, MD

    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
90 Days
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

July 24, 2022

First Posted

July 27, 2022

Study Start

February 3, 2021

Primary Completion

February 3, 2023

Study Completion

May 3, 2023

Last Updated

December 5, 2024

Record last verified: 2024-12

Locations