Dry Eye Under China's Dynamic COVID-zero Strategy

NCT05476068 | Completed DMC

• 1 other identifier: [2022]NO.(001).
• Study Type: observational
• Target: 1,807
• Locations: 1 country
• Sites: 1

Brief Summary

To compare the prevalence of dry eye symptoms and to investigate the association of the risk factors with the dry eye symptomatology among university students in the epidemic and non-epidemic areas of China under the COVID-zero strategy.

Conditions

Dry Eye Symptoms

Keywords

dry eye symptoms; anxiety; depression

Outcome Measures

Primary Outcomes (3)

• A score of ocular surface disease index (OSDI)questionnaire

  Ocular surface disease index (OSDI)questionnaire : (1) OSDI: ≤12 (no DED symptoms), 13 ≤ d ≤ 22 (mild DED symptoms), 23 ≤ d ≤ 32 (moderate DED symptoms), and ≥33 (severe DED symptoms).

  DAY 0

• A score of GAD-7 questionnaire

  GAD-7 questionnaire: (1) 0 \< GAD-7 ≤ 4 (normal), 5 ≤ GAD-7 ≤ 9 (mild anxiety), 10 ≤ GAD-7 ≤ 13 (moderate anxiety), 14 ≤ GAD-7 ≤ 18 (moderate and severe anxiety), and 19 ≤ GAD-7 ≤ 21 (severe anxiety).

  DAY 0

• A score of PHQ-9 questionnaire

  PHQ-9 questionnaire: (1) 0 \< PHQ-9 ≤ 4 (normal), 5 ≤ GAD-7 ≤ 9 (mild depression), 10 ≤ GAD-7 ≤ 14 (moderate depression), 15 ≤ GAD-7 ≤ 19 (moderate and severe depression), and 20 ≤ GAD-7 ≤ 27 (severe depression).

  DAY 0

Secondary Outcomes (3)

• A score of UCLA Loneliness Scale questionnaire

  DAY 0

• Students' increased use of mobile phones

  DAY 0

• Frequency of student sports

  DAY 0

Study Arms (2)

Epidemic area (Nanchang, Nanchang university)

Non-epidemic area (Kaifeng, Henan university)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The subjects of the study are students from Nanchang University and Henan University.

You may qualify if:

• College students with age ≥18 years
• No other medication history in recent 2 weeks;
• Have high compliance and are willing to fill in the questionnaire on time

You may not qualify if:

• routinely using artificial tears and Other eye drops;
• taking any medication that could interfere with the results of the study;
• with any history of eye surgery

Sponsors & Collaborators

• Yifeng Yu: lead

Study Sites (1)

The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330000, China

Location

MeSH Terms

Conditions

Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Deputy chief physician of Ophthalmology center of the Second Affiliated Hospital of Nanchang University

Study Record Dates

• First Submitted: July 23, 2022
• First Posted: July 27, 2022
• Study Start: March 20, 2022
• Primary Completion: May 20, 2022
• Study Completion: May 25, 2022
• Last Updated: July 27, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)