Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker

NCT05473975 | Completed

• 1 other identifier: MOA_2022_3
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Early recanalization is a major prognostic factor in vascular accidents ischemic brain injury (AIC). The acute phase therapies of AIC aim to recanalization by intravenous thrombolysis and/or mechanical thrombectomy. Recanalization is identified immediately during thrombectomy by per-procedural arteriography. For the thrombolysis, only a performed MRI will validate the recanalization. This "proof of concept" study aims to identify an Electro-Encephalographic biomarker (EEG) of the recanalization in real time, the EEG being easy to set up. This biomarker will be sought during recanalization certified by thrombectomy in order to identify the window time for which the biomarker must be sought on the EEG. During this study, the identified EEG biomarker can be used to validate the recanalization during the intravenous thrombolysis in future studies

Conditions

AIS

Outcome Measures

Primary Outcomes (1)

• IElectro-Encephalographic (EEG) marker of recanalization

  dentification of an Electro-Encephalographic (EEG) marker of recanalization in patients with cerebral infarction with proximal occlusion of the sylvian artery and recanalized by mechanical thrombectomy

  inclusion visit

Interventions

Placement of the EGG PROCEDURE

Placement of the EGG before the beginning of the thrombectomy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Inclusions 15 patients hospitalized for an ischemic stroke for whom an MRI identified a proximal sylvian artery occlusion, treatable by mechanical thrombectomy.

You may qualify if:

• Patient over 18 years old
• Presenting a cerebral infarction with proximal occlusion of the sylvian artery requiring thrombectomy
• No objection to participation in the study

You may not qualify if:

• Pregnant or breastfeeding women
• Patient benefiting from legal protection
• Absence of affiliation to a social protection scheme
• Recent cranial surgery not allowing the installation of a scalp EEG

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Ophtalmologique A. de Rothschild

Paris, 75019, France

Location

Study Officials

• Michael OBADIA

  HOPITAL FONDATION Adolphe de ROTHSCHILD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2022
• First Posted: July 26, 2022
• Study Start: January 24, 2023
• Primary Completion: January 23, 2025
• Study Completion: January 23, 2025
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)