Thirst in the Intensive Care Unit, Recognition, Sensitivity and Type

NCT05473351 | Completed

• 1 other identifier: APHP220789
• Study Type: observational
• Target: 203
• Locations: 1 country
• Sites: 3

Brief Summary

Thirst is a perception that provokes the desire to drink liquids. It is a multidimensional symptom that is described in terms of intensity and distress and is associated with dry mouth, called xerostomia. Thirst is poorly recognized in intensive care unit practice. Yet, research has shown that it is one of the most prevalent, most intense, and least well treated symptoms in intensive care patients. Thirst and dry mouth are associated with physical discomfort in the ICU. However, thirst often goes unnoticed and untreated. In this context, The investigators aim to conduct a prospective observational study in mechanically ventilated patients able to communicate to better understand the prevalence, intensity, mechanisms and prognostic value of thirst as well as dry mouth sensation. Primary objective: to assess thirst in mechanically ventilated patients. Primary endpoint: visual analog thirst scale from 0 mm (no thirst) to 100 mm (maximal thirst)

1. 1.Patient 18 years of age and older
2. 2.Patients undergoing invasive mechanical ventilation for at least 24 hours at one of the participating centers
3. 3.No objection to participation in the study During the study period, patients from 3 resuscitation sites are systematically screened for inclusion in the study on a daily basis, between 9:00 am and 12:00 pm.

Conditions

Thirst in Intensive Care Unit (ICU) Practice

Keywords

Thirst; Intensive care unit,; Cohort

Outcome Measures

Primary Outcomes (1)

• :Assessment of thirst in mechanically ventilated patients.

  visual analog thirst scale from 0 mm (no thirst) to 100 mm (maximum thirst)

  Through study completion, an average of 1 year

Secondary Outcomes (6)

• Evaluation of the association between thirst and dry mouth in mechanically ventilated patients.

  Through study completion, an average of 1 year

• Evaluation of the association between thirst and oral status in mechanically ventilated patients.

  Through study completion, an average of 1 year

• valuation of the association between thirst and extracellular volume in ventilated patients

  Through study completion, an average of 1 year

• Evaluation of the association between thirst and anxiety in the mechanically ventilated patient.

  Through study completion, an average of 1 year

• Evaluation of the association between thirst and pain in mechanically ventilated patients.

  Through study completion, an average of 1 year

Study Arms (1)

Thirst

Patients undergoing invasive mechanical ventilation for at least 24 hours in one of the participating centers

Other: Questionnaire

Interventions

Questionnaire OTHER

Visual Analogic Scale

Thirst

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients on invasive mechanical ventilation, admitted to one of the participating centers

You may qualify if:

• Patient 18 years of age and older
• Patients undergoing invasive mechanical ventilation for at least 24 hours at one of the participating centers
• No objection to participation in the study

You may not qualify if:

• Patients unable to communicate verbally and reliably self-report thirst:
• Richmond Agitation-Sedation Scale (RASS) \< -2 or \> +2,
• delirium according to the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) (if confusion is suspected)
• severe cognitive impairment or severe mental illness
• non-French speaking patients
• severe hearing loss.
• Pregnant women
• Adults under legal protection
• Not affiliated to a social security system or not benefiting from such a system

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (3)

Service de médecine intensive et réanimation, hôpital Avicenne

Bobigny, 93000, France

Location

Service de médecine intensive et réanimation, hôpital Saint-Louis

Paris, 75010, France

Location

Service de medecine intensive et réanimation, hôpital Pitié Salpêtrière

Paris, 75013, France

Location

MeSH Terms

Interventions

Surveys and Questionnaires

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 12, 2022
• First Posted: July 25, 2022
• Study Start: December 29, 2022
• Primary Completion: October 29, 2024
• Study Completion: October 29, 2024
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Beginning 3 months and ending 3 years following article publication. Requests out of these time frame can also be submitted to the sponsor
• Access Criteria: Researchers who provide a methodologically sound proposal

Locations

FR (3)