NCT05472987

Brief Summary

This is a randomized trial comparing open retromuscular ventral hernia repair to robotic retromuscular ventral hernia repair.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
14mo left

Started Jul 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress78%
Jul 2022Aug 2027

First Submitted

Initial submission to the registry

July 20, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 25, 2022

Completed
Same day until next milestone

Study Start

First participant enrolled

July 25, 2022

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2027

Last Updated

October 7, 2025

Status Verified

October 1, 2025

Enrollment Period

5 years

First QC Date

July 20, 2022

Last Update Submit

October 2, 2025

Conditions

Keywords

RoboticHerniaVentral herniaOpen herniaMesh

Outcome Measures

Primary Outcomes (1)

  • Length of Stay

    Time in the hospital after the surgery

    30 days

Secondary Outcomes (9)

  • Post-operative wound complications

    30 day and one year

  • Other post operative complications

    30 days

  • Readmission rate

    30 days

  • Opioid consumption

    30 days and one year

  • Acute pain scores

    5 days after surgery

  • +4 more secondary outcomes

Study Arms (2)

Open Ventral Hernia Repair

ACTIVE COMPARATOR

These patients will undergo open retromuscular ventral hernia repairs

Procedure: Ventral Hernia Repair

Robotic Ventral Hernia Repair

ACTIVE COMPARATOR

These patients will undergo robotic retromuscular ventral hernia repairs.

Procedure: Ventral Hernia Repair

Interventions

Patients will undergo retromuscular ventral hernia repair

Open Ventral Hernia RepairRobotic Ventral Hernia Repair

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years and older
  • cm to 15 cm wide hernia midline defects
  • BMI less than or equal to 45
  • Patient deemed both an open and robotic candidate by operating surgeon

You may not qualify if:

  • years old or younger
  • prisoners
  • pregnant patients
  • Emergent patients
  • BMI greater than 45
  • Hernia defects less than 7 cm or greater than 15 cm in width

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

University of Florida Health

Gainesville, Florida, 32608, United States

RECRUITING

Cleveland Clinic

Cleveland, Ohio, 44195, United States

RECRUITING

Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States

RECRUITING

University of Tennessee Medical Center, Knoxville

Knoxville, Tennessee, 37920, United States

RECRUITING

Related Publications (1)

  • Carvalho AC, Woo KP, Ellis RC, Tu C, Miller BT, Prabhu AS, Rosen MJ, Krpata DM, Petro CC, Beffa LR. Robotic versus open ventral hernia repair (ROVHR): a randomized controlled trial protocol. Hernia. 2025 Mar 4;29(1):109. doi: 10.1007/s10029-025-03299-7.

MeSH Terms

Conditions

Hernia, VentralHernia

Condition Hierarchy (Ancestors)

Hernia, AbdominalPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Officials

  • Lucas Beffa, MD

    The Cleveland Clinic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Lucas Beffa, MD

CONTACT

Alvaro Carvalho

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Masking Details
Patients will be blinded to the intervention. The primary outcome will be determined by a surgeon other than the operating surgeon who is blinded to the intervention. Patients will also receive the same dressings over their wounds and an abdominal binder will be placed over the abdomen in attempts to limit the unblinding of the patient.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor of Surgery

Study Record Dates

First Submitted

July 20, 2022

First Posted

July 25, 2022

Study Start

July 25, 2022

Primary Completion (Estimated)

August 1, 2027

Study Completion (Estimated)

August 1, 2027

Last Updated

October 7, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will not share

Locations