Real-Life Study in Diabetic Macular Edema
Real-World Outcomes of Anti-VEGF Treatment for Diabetic Macular Edema in Turkey: A Multicenter Retrospective Study, MARMASIA Study Group
1 other identifier
observational
854
1 country
10
Brief Summary
The goal of this study is to evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in diabetic macular edema (DME) patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2020
10 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 29, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 17, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 15, 2022
CompletedFirst Submitted
Initial submission to the registry
July 1, 2022
CompletedFirst Posted
Study publicly available on registry
July 25, 2022
CompletedJuly 25, 2022
July 1, 2022
1.3 years
July 1, 2022
July 22, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Visit and Intravitreal Injection Numbers
The primary outcomes were changes in best-corrected visual acuity and central macular thickness in the first year and frequency of visits and intravitreal anti-VEGF injections.
First year
Study Arms (5)
3-month follow-up
6-month follow-up
12-month follow-up
24-month follow-up
36-month follow-up
Interventions
Retrospective study
Eligibility Criteria
The records of DME patients treated with an anti-VEGF agent between January 2015 and December 2018
You may qualify if:
- Diabetic macular edema treated with intravitreal anti-VEGF injection
- Having at least 4 or more annual examination visits
You may not qualify if:
- Phacoemulsification surgery in the last 1 month
- PRFK / grid / focal / micropulse in the last 4 months
- Previous intraocular surgery (excluding PPV and phacoemulsification)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (10)
Kocaeli University School of Medicine
Kocaeli, None Selected, 41001, Turkey (Türkiye)
Marmara University School of Medicine
Istanbul, Turkey (Türkiye)
Memorial Şişli Hospital
Istanbul, Turkey (Türkiye)
University Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital
Istanbul, Turkey (Türkiye)
University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital
Istanbul, Turkey (Türkiye)
University of Health Sciences, Haydarpaşa Numune Training and Research Hospital
Istanbul, Turkey (Türkiye)
University of Health Sciences, Ümraniye Training and Research Hospital
Istanbul, Turkey (Türkiye)
University of Health Sciences, Şişli Etfal Training and Research Hospital
Istanbul, Turkey (Türkiye)
University of Health Sciences, Derince Training and Research Hospital
Kocaeli, Turkey (Türkiye)
Sakarya University School of Medicine
Sakarya, Turkey (Türkiye)
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr.
Study Record Dates
First Submitted
July 1, 2022
First Posted
July 25, 2022
Study Start
November 29, 2020
Primary Completion
March 17, 2022
Study Completion
June 15, 2022
Last Updated
July 25, 2022
Record last verified: 2022-07