Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia

NCT05471570 | Completed

• 1 other identifier: tDCSAphasia
• Study Type: interventional
• Target: 4
• Locations: 0 countries
• Sites: N/A

Brief Summary

There are two opposing hypotheses, namely the interference and laterality-shift hypotheses, regarding the role of the right hemisphere (RH) in language recovery following a left hemisphere damage. Transcranial direct current stimulation (tDCS) has received increasing attention as a potential complement to behavioural therapy. This preliminary study aimed to examine the effect of excitatory (anodal) stimulation of right inferior frontal gyrus (IFG) on naming abilities of chronic people with aphasia (PWA) to examine the compensatory versus interference role of RH in language recovery, and to confirm the application of tDCS does not induce adverse effects on other cognitive and language functions.

Conditions

Aphasia

Keywords

tDCS; Aphasia; naming

Outcome Measures

Primary Outcomes (1)

• Picture naming task

  One hundred and sixty pictures of concrete nouns from the Snodgrass and Vanderwart (1980) picture set (colored version) were utilised to measure the percentage of object naming accuracy. In particular, these pictures were divided into Set A (training targets) and Set B (untrained generalization targets), with eighty stimuli in each set.

  Immediately after the end of each treatment session and block

Secondary Outcomes (2)

• language task

  Immediately after the end of each treatment block

• Cognitive task

  Immediately after the end of each treatment block

Study Arms (2)

anodal tDCS

ACTIVE COMPARATOR

20 minutes of one mA anodal High-Definition tDCS (HD-tDCS) over right IFG combined with 40 minutes of naming therapy for five consecutive days in week 1

Device: tDCS stimulation

sham tDCS

SHAM COMPARATOR

20-minutes sham HD-tDCS with 40-minutes therapy of naming therapy for five consecutive days in week 1

Device: tDCS stimulation

Interventions

tDCS stimulation DEVICE

The study examines the effect of excitatory stimulation of right inferior frontal gyrus (IFG) on naming abilities of people with aphasia (PWA) as compared to sham stimulation to examine the compensatory versus interference role of right hemisphere in language recovery after stroke.

Also known as: language therapy

anodal tDCS; sham tDCS

Eligibility Criteria

• Age: 40 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• People with chronic aphasia following the stroke

You may not qualify if:

• history of seizure or epilepsy,
• previous adverse reactions to TMS/tDCS,
• having a pace-maker or a metal implanted in the brain
• being pregnant

Sponsors & Collaborators

• The University of Hong Kong: lead

MeSH Terms

Conditions

Aphasia

Interventions

Transcranial Direct Current Stimulation; Language Therapy

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques; Rehabilitation of Speech and Language Disorders; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: July 18, 2022
• First Posted: July 25, 2022
• Study Start: January 1, 2017
• Primary Completion: November 1, 2017
• Study Completion: December 20, 2017
• Last Updated: November 4, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share