Predictive fActors for toleraNce to Taxane Based CHemotherapy In Older adultS Affected by mEtastatic Prostate Cancer

NCT05471427 | Completed

• 1 other identifier: ANCHISES
• Study Type: observational
• Target: 118
• Locations: 1 country
• Sites: 1

Brief Summary

Aiming to explore predictive factors of fitness to taxane chemotherapy in elderly patients, the investigators collected data from a prospective mono-centric database of patients aged \>/= 70 years old treated in our department, and explored association between baseline age, G8 score and Charlson comorbidity index with taxane dose reduction, treatment temporary suspension or definitive interruption.

Conditions

Elderly Patients; Metastatic Prostate Cancer

Outcome Measures

Primary Outcomes (1)

• Treatment interruption

  Number of participants with definitive treatment stop unrelated to treatment progression

  10 months

Secondary Outcomes (1)

• Treatment suspension

  10 months

Other Outcomes (1)

• Dose reduction

  10 months

Interventions

Taxane chemotherapy DRUG

Patients underwent taxane chemotherapy according to clinical practice for metastatic prostate cancer

Also known as: Docetaxel or Cabazitaxel

Eligibility Criteria

• Age: 70 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients affected by metastatic prostate cancer (either in castrate resistant or hormone sensitive status), undergoing taxane chemotherapy in any setting at an age \>/=70 years old

You may qualify if:

• Patients affected by metastatic prostate cancer
• \>/=70 years old.
• Patients undergoing Taxane treatment with Docetaxel or Cabazitaxel

You may not qualify if:

• Patients younger than 70 years old.
• Patients unsuitable for taxane chemotherapy

Sponsors & Collaborators

• Azienda Ospedaliero-Universitaria Careggi: lead

Study Sites (1)

AOU Careggi Radiation Oncology Unit

Florence, 50134, Italy

Location

Related Publications (19)

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MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Docetaxel; cabazitaxel

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Diterpenes; Terpenes

Study Officials

• Lorenzo LL Livi

  Azienda Ospedaliero-Universitaria Careggi

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Full Professor

Study Record Dates

• First Submitted: July 8, 2022
• First Posted: July 22, 2022
• Study Start: January 1, 2020
• Primary Completion: July 1, 2022
• Study Completion: July 1, 2022
• Last Updated: July 22, 2022

Record last verified: 2022-07

Locations

IT (1)