Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema

NCT05466604 | Completed Phase 4

• 1 other identifier: YDU/2019//74-921
• Study Type: interventional
• Target: 60
• Locations: 2 countries
• Sites: 2

Brief Summary

The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection. For this purpose, 60 participants with symmetrical mandibular wisdom teeth enrolled the present study. All measurements and evaluations were performed before and 1, 2, 3, and 7 days later the operation.

Conditions

Edema; Pain; Trismus; Infection, Surgical Site

Keywords

postoperative edema; wisdom teeth; trismus; pain control; wound infection

Outcome Measures

Primary Outcomes (92)

• evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase experimental group

  preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase experimental group

  postoperative 1. day

• evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase experimental group

  preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase experimental group

  postoperative 2. day

• evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase experimental group

  preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase experimental group

  postoperative 3. day

• evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase experimental group

  preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase experimental group

  postoperative 7. day

• evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase control group

  preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase control group

  postoperative 1. day

• evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase control group

  preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase control group

  postoperative 2. day

• evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase control group

  preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase control group

  postoperative 3. day

• evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase control group

  preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase control group

  postoperative 7. day

• evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone experimental group

  preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone experimental group

  postoperative 1. day

• evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone experimental group

  preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone experimental group

  postoperative 2. day

• evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone experimental group

  preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone experimental group

  postoperative 3. day

• evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone experimental group

  preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone experimental group

  postoperative 7. day

• evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone control group

  preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone controlgroup

  postoperative 1. day

• evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone control group

  preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone controlgroup

  postoperative 2. day

• evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone control group

  preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone controlgroup

  postoperative 3. day

• evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone control group

  preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone controlgroup

  postoperative 7. day

• evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 1. day using a measuring tape

  edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 1. day

  postoperative 1. day

• evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 2. day using a measuring tape

  edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 2. day

  postoperative 2. day

• evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 3. day using a measuring tape

  edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 3. day

  postoperative 3. day

• evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 7. day using a measuring tape

  edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 7. day

  postoperative 7. day

• evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 1. day using a measuring tape

  edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 1. day

  postoperative 1. day

• evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 2. day using a measuring tape

  edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 2. day

  postoperative 2. day

• evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 3. day using a measuring tape

  edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 3. day

  postoperative 3. day

• evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 7. day using a measuring tape

  edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 7. day

  postoperative 7. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 1. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day

  postoperative 1. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 2. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day

  postoperative 2. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 3. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day

  postoperative 3. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 4. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day

  postoperative 4. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 5. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day

  postoperative 5. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 6. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day

  postoperative 6. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 7. day

  pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day

  postoperative 7. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 1. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day

  postoperative 1. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 2. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day

  postoperative 2. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 3. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day

  postoperative 3. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 4. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day

  postoperative 4. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 5. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day

  postoperative 5. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 6. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day

  postoperative 6. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 7. day

  pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day

  postoperative 7. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 1. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day

  postoperative 1. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 2. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day

  postoperative 2. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 3. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day

  postoperative 3. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 4. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day

  postoperative 4. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 5. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day

  postoperative 5. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 6. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day

  postoperative 6. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 7. day

  pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day

  postoperative 7. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 1. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day

  postoperative 1. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 2. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day

  postoperative 2. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 3. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day

  postoperative 3. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 4. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day

  postoperative 4. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 5. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day

  postoperative 5. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 6. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day

  postoperative 6. day

• evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 7. day

  pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day

  postoperative 7. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group preoperatively.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  preoperative

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 1. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 1. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 2. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 2. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 3. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 3. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 7. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 7. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group preoperatively.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  preoperative

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 1. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 1. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 2. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 2. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 3. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 3. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 7. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 7. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group preoperatively.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  preoperative

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 1. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 1. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 2. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 2. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 3. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 3. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 7. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 7. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group preoperatively.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  preoperative

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 1. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 1. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 2. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 2. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 3. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 3. day

• evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 7. day.

  amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler

  postoperative 7. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group preoperatively.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  preoperative

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 1. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 1. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 2. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 2. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 3. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 3. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 7. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 7. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group preoperatively.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  preoperative

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 1. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 1. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 2. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 2. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 3. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 3. day

• evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 7. day.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 7. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group preoperatively.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  preoperative

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 1. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 1. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 2. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 2. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 3. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 3. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 7. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 7. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group preoperatively.

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  preoperatively

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 1. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 1. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 2. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 2. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 3. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 3. day

• evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 7. day

  existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

  postoperative 7. day

Study Arms (4)

hyaluronidase

EXPERIMENTAL

Drug: Hyaluronidase Injection mesomedica

hyaluronidase control

NO INTERVENTION

dexamethasone

EXPERIMENTAL

Drug: Dexamethasone dekort

dexamethasone control

NO INTERVENTION

Interventions

Hyaluronidase Injection mesomedica DRUG

injection of 150 IU hyaluronidase to perioperative region, submucosally.

hyaluronidase

Dexamethasone dekort DRUG

injection of 8 mg dexamethasone to perioperative region, submucosally.

dexamethasone

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• symmetrical mandibular wisdom teeth with bone retention
• patients who are signed informed consent and acceptance of study involvement forms

You may not qualify if:

• existence of any systemic disease
• existence of any periodical drug intake
• existence of difference in operation times of right and left impacted wisdom teeth extractions more than 5 minutes
• existence of pregnancy
• existence of breastfeeding

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (2)

Near East University

Nicosia, 99138, Cyprus

Location

Hacettepe University

Ankara, Sıhhiye, 06100, Turkey (Türkiye)

Location

Related Publications (1)

• Koc O, Er N, Karaca C, Bilginaylar K. Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery. BMC Oral Health. 2024 Aug 30;24(1):1018. doi: 10.1186/s12903-024-04729-1.

  PMID: 39215323 DERIVED

MeSH Terms

Conditions

Edema; Pain; Trismus; Surgical Wound Infection; Agnosia; Wound Infection

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurologic Manifestations; Spasm; Neuromuscular Manifestations; Nervous System Diseases; Infections; Postoperative Complications; Pathologic Processes; Perceptual Disorders; Neurobehavioral Manifestations

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: July 13, 2022
• First Posted: July 20, 2022
• Study Start: December 1, 2019
• Primary Completion: June 30, 2022
• Study Completion: June 30, 2022
• Last Updated: July 20, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1); CY (1)