Perception of Electrical Stimuli in Individuals With Stroke

NCT05465005 | Active Not Recruiting

• 1 other identifier: K25HD096116
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

To successfully manipulate objects in one's surroundings, such as when lifting a cup, one must accurately perceive their physical interactions. This includes accurately interpreting the tactile cues arising at one's fingertips when touching an object. Currently, tactile perception is assessed in individuals with stroke using passive protocols. Research has yet to explore whether activating one's muscles impacts the tactile perceptual process in individuals with stroke despite previous research demonstrating the effect of muscle activation on tactile perception in individuals who are neurologically intact. The proposed research will be the first to address the impact of muscle activation, in addition to stroke, on tactile perception. As such, the proposed research is significant for advancing our understanding of the extent to which tactile deficits occur in individuals with stroke, particularly during volitional movement.

Conditions

Stroke

Keywords

tactile perception; somatosensation; muscle activation

Outcome Measures

Primary Outcomes (1)

• Detection threshold

  Minimum magnitude of current at which an electrical stimulus can be detected

  ~5 minutes

Interventions

Torque Generation BEHAVIORAL

Relaxed, or flexing about the elbow to 25% or 50% of the maximum elbow torque that one can generate.

Also known as: Muscle activation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For the participants with stroke, i) a single unilateral cortical lesion that took place at least one year prior and ii) an absence of comorbid neurological impairments
• Ability to understand and complete the experimental tasks
• Capacity to provide informed consent
• At least 18 years of age

You may not qualify if:

• Major injury to either arm
• Sensory neuropathy

Sponsors & Collaborators

• Netta Gurari: lead
• Northwestern University: collaborator
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator
• Virginia Polytechnic Institute and State University: collaborator

Study Sites (1)

Virginia Tech Biomedical Engineering and Mechanics

Blacksburg, Virginia, 24061, United States

Location

Related Publications (7)

• Post LJ, Zompa IC, Chapman CE. Perception of vibrotactile stimuli during motor activity in human subjects. Exp Brain Res. 1994;100(1):107-20. doi: 10.1007/BF00227283.

  PMID: 7813639 BACKGROUND

• Chapman, C. E., Zompa, I. C., Williams, S. R., Shenasa, J. & Jiang, W. Factors influencing the perception of tactile stimuli during movement. in Somesthesis and the Neurobiology of the Somatosensory Cortex (eds. Franzén, O., Johansson, R. & Terenius, L.) 307-320 (Birkhäuser Basel, 1996).

  BACKGROUND

• Seki K, Perlmutter SI, Fetz EE. Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement. Nat Neurosci. 2003 Dec;6(12):1309-16. doi: 10.1038/nn1154. Epub 2003 Nov 16.

  PMID: 14625555 BACKGROUND

• Pavlenko, V. B. Self-initiated motor behavioral act-related neuronal activity in the cat Locus Coeruleus. Neurophysiology 35, 29-37 (2003).

  BACKGROUND

• Wei K, Glaser JI, Deng L, Thompson CK, Stevenson IH, Wang Q, Hornby TG, Heckman CJ, Kording KP. Serotonin affects movement gain control in the spinal cord. J Neurosci. 2014 Sep 17;34(38):12690-700. doi: 10.1523/JNEUROSCI.1855-14.2014.

  PMID: 25232107 BACKGROUND

• Jacobs BL, Martin-Cora FJ, Fornal CA. Activity of medullary serotonergic neurons in freely moving animals. Brain Res Brain Res Rev. 2002 Oct;40(1-3):45-52. doi: 10.1016/s0165-0173(02)00187-x.

  PMID: 12589905 BACKGROUND

• Seki K, Fetz EE. Gating of sensory input at spinal and cortical levels during preparation and execution of voluntary movement. J Neurosci. 2012 Jan 18;32(3):890-902. doi: 10.1523/JNEUROSCI.4958-11.2012.

  PMID: 22262887 BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Model Details: We will compare outcome measures across three experimental conditions and each upper extremity in participants with stroke and similarly-aged controls.

Study Record Dates

• First Submitted: July 15, 2022
• First Posted: July 19, 2022
• Study Start: February 1, 2022
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)