Safety, Tolerability and Pharmacokinetics Study of QLS31904 in Patients With Advanced Solid Tumors

NCT05461287 | Unknown Phase 1

• 1 other identifier: QLS31904-101
• Study Type: interventional
• Target: 290
• Locations: 1 country
• Sites: 1

Brief Summary

This is an open label, phase 1 clinical study to evaluate the safety, tolerability, dose limiting toxicities (DLTs), maximum tolerated dose (MTD) or maximum administered dose (MAD) and recommended phase 2 dose (RP2D) of QLS31904 q2w/q3w intravenous use in patients with advanced solid tumors. Additional objectives are to characterise pharmacokinetics and pharmacodynamics, and to evaluate efficacy signals. This study is consisted of phase Ia (Dose Escalation) and phase Ib (Dose Expansion). Phase Ib will further explore QLS31904 in selected patients populations based on data from phase Ia. The Phase Ib objectives, endpoints and design will be specified in a study protocol amendment after availability of phase Ia results.

Conditions

Advanced Solid Tumor

Outcome Measures

Primary Outcomes (3)

• DLT

  Dose-limiting toxicity (DLT) is defined as any of the specified toxicities evaluated as at least possibly related with the study drug within 28 days after the first dose.

  Up to 28 approximately days

• MTD

  The maximum tolerated dose (MTD) is defined as the highest dose at which DLT occurs in \<1/3 subjects. The maximum administrated dose (MAD) is defined as the highest dose of all groups if MTD can not be determined.

  Up to 24 approximately months

• RP2D

  Recommended dose for phase II trials

  Up to 24 approximately months

Secondary Outcomes (22)

• Incidence of adverse event (AE)

  Up to 24 approximately months

• Severity of adverse event (AE)

  Up to 24 approximately months

• Incidence of serious adverse event (SAE)

  Up to 24 approximately months

• Severity of serious adverse event (SAE)

  Up to 24 approximately months

• Incidence of immune related adverse event (irAE)

  Up to 24 approximately months

Other Outcomes (2)

• DLL3 expression in tumor tissue

  Up to 24 approximately months

• Objective response based on iRECIST criteria in patients with measurable disease

  Up to 24 approximately months

Study Arms (1)

QLS31904

EXPERIMENTAL

Qls31904 is a bi-specific recombinant protein construct containing 2 humanized antibody derived binding domains.

Drug: QLS31904

Interventions

QLS31904 DRUG

QLS31904 ONLY

QLS31904

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Understanding and voluntarily signing the informed consent form;
• Male or female, age≥18 years;
• Patients with histologically or cytologically confirmed advanced solid tumors including small cell lung cancer, small cell cancers in other organs or neuroendocrine carcinoma who have progression after on theor intolerance to standard of care, or have no effective standard therapeutic regimen;
• Tumours must be confirmed expression of DLL3.
• Presence of at least one measurable lesion meeting the requirements in RECIST v1.1 evaluation criteria;
• ECOG PS score: 0\~1;
• Patients with life expectancy ≥3 months;

You may not qualify if:

• Having received the treatment targeting CD3 or DLL3 previously;
• Receiving any systematic antitumor therapy or other investigational product within 4 weeks prior to the first dose of QLS31904;
• Receiving radiotherapy within 2 weeks prior to the first dose of QLS31904;
• For the dose-escalation, participants who experienced severe immune-mediated AEs while on treatment with Immune checkpoint inhibitors (e.g., anti PD-L1, anti PD-1, anti CTLA-4) ;
• Symptomatic central nervous system (CNS) metastasis.
• History of concurrent serious cerebro- and cardiovascular diseases including but not limited to: unstable angina pectoris, myocardial infarction, cerebrovascular accident or transient ischemic attack within 6 months prior to the first doses, poorly controlled hypertension or arrhythmia, or any other arterial thrombosis or embolic event;
• History of concurrent gastrointestinal diseases including but not limited to: gastrointestinal bleeding or perforation, acute pancreatitis;
• History of concurrent lung damage including but not limited to: interstitial lung disease, other diseases requiring oxygen inhalation.
• Presence of active pneumonia or history of noninfectious pneumonia;
• Active infection requiring systematic treatment/antibiotics or intravenous use of systemic anti-infection therapy with one week prior to the first dose or use for more than 7 days;
• Known positive for human immunodeficiency virus (HIV); Having evidence on infection of hepatitis C virus (HCV) or syphilis; Hepatitis B virus (HBV) infected individuals with positive HBsAg and HBV DNA copy \>1000 IU/ml or 200 cps/mL; Following treatment according to guidelines, previously HBV infected individuals in screening period can be enrolled only;
• Presence of active or suspicious autoimmune disease.
• Previous allogeneic bone marrow transplantation or solid organ transplantation;
• Major surgery (judged by investigators) or in the recovery period of the surgery within 4 weeks before the first dose of QLS31904.
• Vaccination of live attenuated vaccine within 4 weeks prior to the first dose of QLS31904;

Sponsors & Collaborators

• Qilu Pharmaceutical Co., Ltd.: lead

Study Sites (1)

Jilin Cancer Hospital

Changchun, Jilin, 132000, China

RECRUITING

Central Study Contacts

Huayuan Wang

CONTACT

008610-50813552; huayuan.wang@qilu-pharma.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 13, 2022
• First Posted: July 18, 2022
• Study Start: September 30, 2022
• Primary Completion: September 25, 2024
• Study Completion: May 25, 2025
• Last Updated: November 10, 2022

Record last verified: 2022-11

Locations

CN (1)