Plasma Neurofilament Light and Its Relationship With Omega-3 Status and Soccer Heading in Women Soccer Players

NCT05457023 | Completed

• 1 other identifier: STUDY00148618
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this study is to (1) assess how a competitive season of purposeful gameplay soccer heading in collegiate women soccer players is related to a blood biomarker for sports-related brain injury, plasma neurofilament light (NF-L), and (2) examine how a player's omega-3 status is related to plasma NF-L concentration changes during and after a competitive season of gameplay soccer heading.

Conditions

Brain Trauma

Keywords

Soccer, Heading, Omega-3, Neurofilament Light, Subconcussive, Women

Outcome Measures

Primary Outcomes (3)

• Change in plasma neurofilament light concentrations from baseline, during, and after a competitive season.

  Plasma neurofilament light (pg/mL) is a biomarker of axonal brain injury following sports-related head impacts.

  Baseline, 1 Months, 2 Months, 3 Months, 6 Months

• Change in purposeful soccer heading frequencies from baseline, during, and after a competitive season.

  HeadCount is a web-based, structured, self-administered questionnaire to assess longer-term heading frequencies (#) during competitive play and is administered bi-weekly.

  Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 14 weeks

• Change in Omega-3 status from baseline, during, and after a competitive season.

  Omega-3 Index (%) is the omega-3 fatty acid content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) within membrane of red blood cell. It is expressed as EPA+DHA as a percent of total identified fatty acids.

  Baseline, 1 Months, 2 Months, 3 Months, 6 Months

Study Arms (1)

Collegiate Women Soccer Players

National Collegiate Athletic Association (NCAA) players.

Other: Plasma Neurofilament Light (NF-L); Other: Omega-3 Index; Other: HeadCount Questionnaire

Interventions

Plasma Neurofilament Light (NF-L) OTHER

Plasma NF-L is a biomarker of axonal brain injury following sports-related head impacts.

Collegiate Women Soccer Players

Omega-3 Index OTHER

Omega-3 Index is the omega-3 fatty acid content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) within the erythrocyte cell membrane. It is expressed as EPA+DHA as a percent of total identified fatty acids.

Collegiate Women Soccer Players

HeadCount Questionnaire OTHER

HeadCount is a web-based, structured, self-administered questionnaire to assess longer-term heading exposure during competitive play and is administered bi-weekly.

Collegiate Women Soccer Players

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Collegiate women soccer players who actively compete at the NCAA Division 1-A competition level.

You may qualify if:

• At least 18 years of age.
• Active player on the university's current team roster for the upcoming competitive season.
• Is eligible to participate in games and is not redshirting.

You may not qualify if:

• Is recovering from a Physician diagnosed concussion.
• Is recovering from another injury prohibiting the study participant from participating in all sport-related activities.

Sponsors & Collaborators

• University of Kansas Medical Center: lead

Study Sites (2)

University of Missouri Kansas City

Kansas City, Missouri, 64108, United States

Location

Rockhurst University

Kansas City, Missouri, 64110, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Plasma

MeSH Terms

Conditions

Brain Injuries, Traumatic; Charcot-Marie-Tooth disease, Type 1F

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Aaron F Carbuhn, PhD

  University of Kansas Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 7, 2022
• First Posted: July 13, 2022
• Study Start: July 28, 2022
• Primary Completion: November 9, 2023
• Study Completion: November 9, 2023
• Last Updated: November 13, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)