Artificial Intelligence for Infant Motor Screening: Development and Validation

NCT05456126 | Completed

• 1 other identifier: 202012089RINB
• Study Type: observational
• Target: 122
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this three-year study is therefore three-fold: (1) Model Development- to apply pose estimation model and tracking recognition model on the movements of a large sample of term and preterm infants under a motor assessment in the laboratory to examine the accuracy of the AI algorithms in identifying individual movements using physical therapists' results as gold standards; (2) Model Validation- to examine the performance of the AI algorithms on the same term and preterm infants' movements when video recorded by the parents at home between the laboratory assessment ages using physical therapists' results as gold standards; and (3) Concurrent and Predictive Validity of AI Movement Sets- to select the identifiable movement classes into AI movement sets for individual ages to examine their concurrent validity with physical therapists' results and predictive validity on developmental outcomes at 18 months of age in these infants.

Conditions

Motor Disorders

Keywords

Artificial intelligence; Infant; Machine Learning; Motor Development; Screening

Outcome Measures

Primary Outcomes (3)

• Alberta Infant Motor Scale (AIMS)

  motor function in supine, prone, sitting and standing position

  4-18 months of age

• Age of walking attainment

  Age of attaining independent walking for at least five steps

  10-18 months of age

• Peabody Developmental Motor Scale- 2nd edition (PDMS-II)

  The motor scale is composed of gross and fine motor items

  18 months of age

Study Arms (2)

Term infants

The inclusion criteria for term infants are: gestational age 37-42 weeks, birth weight \>2,500 grams, aged 2-4 months, and no congenital/genetic abnormalities. Their mothers are older than 20 years of age, have no history of alcohol or drug abuse, and are married or live with fathers.

Preterm infants

The inclusion criteria for preterm infants are: gestational age \<37 weeks, birth weight \<2,500 grams, aged 2-4 months (corrected for prematurity), and no congenital/genetic abnormalities. Their mothers are older than 20 years of age, have no history of alcohol or drug abuse, and are married or live with fathers.

Eligibility Criteria

• Age: 4 Months - 18 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This study will prospectively recruit term and preterm infants from National Taiwan University Children's Hospital, Taipei, Taiwan. Infants will be recruited from the neonatal and well-baby follow-up clinic of the hospital. The proportion of boys and girls in the sample will be balanced. The parents will be informed of the study and will sign a written consent form before participation in the study. This study is currently under human right review by National Taiwan University Hospital.

You may qualify if:

• Their mothers are older than 20 years of age, have no history of alcohol or drug abuse, and are married or live with fathers.

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Health Research Institutes, Taiwan: collaborator

Study Sites (1)

National Taiwan University

Taipei, 100, Taiwan

Location

MeSH Terms

Conditions

Motor Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Study Officials

• Suh-Fang Jeng, Professor

  School and Graduate Institute of Physical Therapy, National Taiwan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2022
• First Posted: July 13, 2022
• Study Start: August 1, 2021
• Primary Completion: May 17, 2025
• Study Completion: May 17, 2025
• Last Updated: November 18, 2025

Record last verified: 2025-09

Locations

TW (1)