MultiMorbidity Life-Course Approach To Myocardial Health -A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD)

NCT05455125 | Unknown DMC

• 1 other identifier: 123172
• Study Type: observational
• Target: 550
• Locations: 1 country
• Sites: 1

Brief Summary

Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world's longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46-the cardiac sub-study of the NSHD. Methods and expected results The investigators aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow the investigators hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium. Conclusion By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR-ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age.

Conditions

Frailty; Cardiovascular Diseases

Outcome Measures

Primary Outcomes (4)

• CMR phenotype - T1

  This will be assessed through a 45 minute cardiac MRI scan with perfusion.

  Through study completion, an average of 4 years.

• CMR phenotype - T2

  This will be assessed through a 45 minute cardiac MRI scan with perfusion.

  Through study completion, an average of 4 years.

• CMR phenotype - Myocardial blood flow

  This will be assessed through a 45 minute cardiac MRI scan with perfusion.

  Through study completion, an average of 4 years.

• CMR phenotype - Aortic blood flow

  This will be assessed through a 45 minute cardiac MRI scan with perfusion.

  Through study completion, an average of 4 years.

Interventions

CMR CGI DIAGNOSTIC_TEST

High resolution ECGI plus advanced CMR

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

NSHD cohort

You may qualify if:

• NSHD study member.
• Who is still alive and agreed to take part in the study.

You may not qualify if:

• Pacemaker.
• Implantable cardio defibrillator.
• Atrial fibrillation.
• Complete heart block.
• Severe asthma.

Sponsors & Collaborators

• University College, London: lead

Study Sites (1)

UCL Bloomsbury Centre for Clinical Phenotyping

London, SW13 0JD, United Kingdom

RECRUITING

Related Publications (2)

• Topriceanu CC, Webber M, Shiwani H, Chan F, Martin E, Falconer D, Stanley MA, Bennett J, Gonzalez-Martin P, Shah H, De S, Wong A, Pierce I, Davies RH, Lambiase PD, Chaturvedi N, Kellman P, Hardy R, Moon JC, Hughes AD, Captur G. Higher Life-Course Blood Pressure Associates With Reduced Myocardial Perfusion in Older Age: Insights From MyoFit46. Circ Cardiovasc Imaging. 2025 Nov 8:e019105. doi: 10.1161/CIRCIMAGING.125.019105. Online ahead of print.

  PMID: 41404671 DERIVED

• Webber M, Joy G, Bennett J, Chan F, Falconer D, Shiwani H, Davies RH, Krausz G, Tanackovic S, Guger C, Gonzalez P, Martin E, Wong A, Rapala A, Direk K, Kellman P, Pierce I, Rudy Y, Vijayakumar R, Chaturvedi N, Hughes AD, Moon JC, Lambiase PD, Tao X, Koncar V, Orini M, Captur G. Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging. J Cardiovasc Magn Reson. 2023 Dec 4;25(1):73. doi: 10.1186/s12968-023-00980-7.

  PMID: 38044439 DERIVED

MeSH Terms

Conditions

Frailty; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Gabriella Captur, MD PhD MSc MRCP

CONTACT

+447809621264; gabycaptur@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 16, 2022
• First Posted: July 13, 2022
• Study Start: July 1, 2020
• Primary Completion: June 30, 2024
• Study Completion: June 30, 2024
• Last Updated: July 13, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)