The Bronx-Valve Registry

NCT05453526 | Completed

• 1 other identifier: 2022-13933
• Study Type: observational
• Target: 330,570
• Locations: 1 country
• Sites: 1

Brief Summary

The Bronx-Valve Registry is designed to collect and assess data on all patients with valvular diseases referred to Montefiore Medical Center for echocardiographic exams. Valvular heart disease (VHD) is a major focus of cardiovascular medicine, but limited data are available for racial and ethnic minorities. The aim was to assess the burden and clinical correlates of VHD in a highly diverse area of the United States.

Conditions

Valvular Heart Disease

Keywords

valvular heart disease; race; ethnicity; diversity; mitral valve; aortic valve; tricuspid valve; pulmonary valve; stenosis; regurgitation; echocardiography

Outcome Measures

Primary Outcomes (3)

• Racial/ethnical based differences in baseline characteristics and valvular heart disease

  Baseline characteristics among pre-defined racial/ethnical groups will be compared for each valvular heart disease

  Baseline

• Prevalence of Valvular Heart Disease

  Prevalence of each valvular heart disease will be compared among pre-defined racial/ethnical groups

  Up to 10 years

• All-cause mortality

  All-cause mortality according to valvular heart disease and racial/ethnical group

  Up to 10 years

Study Arms (6)

Race - American Indian or Alaska Native

Being identified as American Indian or Alaska Native

Race - Asian

Being identified as Asian

Race - Black or African-American

Being identified as Black or African-American

Race - Native Hawaiian or Other Pacific Islander

Being identified as Native Hawaiian or Other Pacific Islander

Race - White

Being identified as White

Ethnicity - Spanish/Hispanic/Latino

Being identified as Spanish/Hispanic/Latino

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult patients undergoing echocardiographic assessment at Montefiore Medical Center (Bronx, NY, USA) will be included in this registry.

You may qualify if:

• Minimum age of 18 years old
• Undergoing transthoracic or transesophageal echocardiographic assessment at Montefiore Medical Center or affiliated institutions in the Bronx (NY, USA)

You may not qualify if:

• Age below 18 years old
• No available information regarding race or ethnicity

Sponsors & Collaborators

• Montefiore Medical Center: lead

Study Sites (1)

Montefiore Medical Center

The Bronx, New York, 10461, United States

Location

Related Publications (2)

• Echarte-Morales J, Scotti A, Bonnet G, Torrado J, Sturla M, Coisne A, Ludwig S, Barzallo D, Escabia C, Chandra A, Kodesh A, Aftab A, Granada JF, Ho EC, Jorde UP, Rodriguez CJ, Slipczuk L, Garcia MJ, Latib A. Racial and ethnic disparities in patients with severe tricuspid regurgitation: The Bronx-Valve registry. Int J Cardiol. 2025 Feb 15;421:132889. doi: 10.1016/j.ijcard.2024.132889. Epub 2024 Dec 6.

  PMID: 39647784 RESULT

• Scotti A, Sturla M, Echarte-Morales J, Ho EC, Millin A, Coisne A, Ludwig S, Leone PP, Rosiene J, Granada JF, Goldberg Y, Pu M, Jorde UP, Slipczuk L, Rodriguez CJ, Garcia MJ, Latib A. Burden of Valvular Heart Diseases in a Racially and Ethnically Diverse Population: The Bronx-Valve Registry. J Am Heart Assoc. 2025 Jan 21;14(2):e035378. doi: 10.1161/JAHA.124.035378. Epub 2025 Jan 16.

  PMID: 39817520 RESULT

MeSH Terms

Conditions

Heart Valve Diseases; Constriction, Pathologic; Gastroesophageal Reflux

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Esophageal Motility Disorders; Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Azeem Latib, MD

  Montefiore Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 1, 2022
• First Posted: July 12, 2022
• Study Start: January 1, 2010
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: February 3, 2025

Record last verified: 2025-01

Locations

US (1)