Blood Flow Restriction Resistance Training Intervention on Vascular Function

NCT05451641 | Completed

• 1 other identifier: STUDY00002999
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of blood flow restriction (BFR) resistance training on vascular function. The investigators aim to compare the effects of different BFR devices (wide-rigid cuffs and narrow elastic bands) on vascular function. The investigators hypothesize that BFR resistance training with wide-rigid cuffs might have a minor negative effect (short-term and reversible) on vascular function, while BFR resistance training with narrow-elastic bands may improve vascular function. Both training methods are equally effective in increasing muscle strength.

Conditions

Endothelial Function

Outcome Measures

Primary Outcomes (3)

• Change from baseline vascular function at 2 weeks

  Flow-mediated dilation evaluated by an ultrasound machine

  Baseline measurement and measurement at 2 weeks

• Change from baseline muscle strength at 2 weeks

  Measured by a cable machine in the gym

  Baseline measurement and measurement at 2 weeks

• Change from baseline grip strength at 2 weeks

  Measured by a hand dynamometer

  Baseline measurement and measurement at 2 weeks

Secondary Outcomes (10)

• Change from baseline body fat percentage at 2 weeks

  Baseline measurement and measurement at 2 weeks

• Change from baseline fat mass at 2 weeks

  Baseline measurement and measurement at 2 weeks

• Change from baseline lean body mass at 2 weeks

  Baseline measurement and measurement at 2 weeks

• Blood flow responses to different types of cuff

  Baseline measurement

• Blood flow responses to different types of cuff

  At 2 weeks

Study Arms (2)

Wide-rigid cuff

EXPERIMENTAL

The wide-rigid cuff will be randomly assigned to one of the subject's arms.

Behavioral: Blood flow restriction resistance training

Narrow-elastic band

EXPERIMENTAL

The narrow-elastic band will be randomly assigned to another arm of the subject.

Behavioral: Blood flow restriction resistance training

Interventions

Blood flow restriction resistance training BEHAVIORAL

The participants will receive a 2-week exercise training program (3 times per week). Each training session will consist of 3 resistance training exercises with two blood flow restriction devices (wide-rigid cuff and narrow-elastic band). For both arms, the participants will perform the same exercise with different BFR devices.

Narrow-elastic band; Wide-rigid cuff

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Apparently healthy, sedentary or recreationally active young adults aged between 18 - 40 years old and signed the informed consent.

You may not qualify if:

• A current COVID-19 diagnosis
• morbid obesity
• hypertension
• smoking
• overt cardiovascular disease
• using any medication that might affect the cardiovascular system
• current participation in resistance training.

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

Cardiovascular Aging Research Laboratory

Austin, Texas, 78705, United States

Location

Related Publications (7)

• Lixandrao ME, Ugrinowitsch C, Berton R, Vechin FC, Conceicao MS, Damas F, Libardi CA, Roschel H. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis. Sports Med. 2018 Feb;48(2):361-378. doi: 10.1007/s40279-017-0795-y.

  PMID: 29043659 BACKGROUND

• Pearson SJ, Hussain SR. A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy. Sports Med. 2015 Feb;45(2):187-200. doi: 10.1007/s40279-014-0264-9.

  PMID: 25249278 BACKGROUND

• Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892.

  PMID: 33344005 BACKGROUND

• Hunt JE, Galea D, Tufft G, Bunce D, Ferguson RA. Time course of regional vascular adaptations to low load resistance training with blood flow restriction. J Appl Physiol (1985). 2013 Aug 1;115(3):403-11. doi: 10.1152/japplphysiol.00040.2013. Epub 2013 May 23.

  PMID: 23703116 BACKGROUND

• Horiuchi M, Okita K. Blood flow restricted exercise and vascular function. Int J Vasc Med. 2012;2012:543218. doi: 10.1155/2012/543218. Epub 2012 Oct 22.

  PMID: 23133756 BACKGROUND

• Alhejily W, Aleksi A, Martin BJ, Anderson TJ. The effect of ischemia-reperfusion injury on measures of vascular function. Clin Hemorheol Microcirc. 2014;56(3):265-71. doi: 10.3233/CH-131741.

  PMID: 23719421 BACKGROUND

• Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension. 2009 Jun;53(6):986-92. doi: 10.1161/HYPERTENSIONAHA.109.131508. Epub 2009 Apr 20.

  PMID: 19380611 BACKGROUND

Study Officials

• Hirofumi Tanaka, PhD

  The University of Texas at Austin

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 22, 2022
• First Posted: July 11, 2022
• Study Start: September 20, 2022
• Primary Completion: September 1, 2024
• Study Completion: September 19, 2024
• Last Updated: December 6, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)