The Effects of General Anesthesia and Combined Anesthesia in Controlled Hypotension During Arthroscopic Shoulder Surgery

NCT05451550 | Unknown

• 1 other identifier: Gang202207
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Controlled hypotension is one of the important techniques used for facilitates the clarity of the surgical field during arthroscopic shoulder surgery. Brachial plexus or its branches block provides excellent analgesia during arthroscopic shoulder surgery. To test the hypothesis that, during arthroscopic shoulder surgery, general anesthesia combined with nerve block could provide more stable hemodynamic index than general anesthesia. Patients undergoing arthroscopic shoulder surgery were enrolled and divided into 3 groups: general anesthesia group, general anesthesia combined with brachial plexus block, and general anesthesia combined with suprascapular nerve block group. The dosage of vasoactive drugs and anesthetics, parameters of perioperative bleeding, hemodynamic parameters, systemic oxygen metabolism, kidney functions, as well as procedure process and postoperative adverse reactions were recorded and compared between the groups.

Conditions

Shoulder Injuries; Shoulder Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• The dosage of total vasopressor-inotrope dose between groups

  The dosage of total vasopressor-inotrope dose (Calculate by formula) between the groups

  1 day

Secondary Outcomes (3)

• The dosage of anesthetics between groups

  1 day

• Blood pressure between the groups

  1 day

• The incidence of postoperative complications

  3 day

Study Arms (3)

General anesthesia group

EXPERIMENTAL

Patients were maintained with propofol/remifentanil in general anesthesia

Procedure: General anesthesia

General anesthesia combined with brachial plexus block group

EXPERIMENTAL

An additional ultrasound-guided brachial plexus block were performed

Procedure: Brachial plexus block; Procedure: General anesthesia

general anesthesia combined with suprascapular nerve block group

EXPERIMENTAL

An additional ultrasound-guided suprascapular nerve block were performed

Procedure: General anesthesia; Procedure: Suprascapular nerve block

Interventions

Brachial plexus block PROCEDURE

An additional ultrasound-guided suprascapular nerve block(0.375% ropivacaine) were performed before general anesthesia induction in general anesthesia combined with brachial plexus block group

Also known as: General anesthesia combined with brachial plexus block group

General anesthesia combined with brachial plexus block group

General anesthesia PROCEDURE

General anesthesia were performed according to clinical routine: induction drugs: propofol, sufentanil, rocuronium, maintenance drugs: propofol, sevoflurane and remifentanil, Laryngeal mask ventilation.

General anesthesia combined with brachial plexus block group; General anesthesia group; general anesthesia combined with suprascapular nerve block group

Suprascapular nerve block PROCEDURE

An additional ultrasound-guided suprascapular nerve block(0.375% ropivacaine) were performed before general anesthesia induction in general anesthesia combined with brachial plexus block group

Also known as: General anesthesia combined with suprascapular nerve block group

general anesthesia combined with suprascapular nerve block group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• (1) planned elective arthroscopic shoulder surgery, need controlled hypotension under general anesthesia; (2) aged 60-75 years; (3) ASA grade II or III; and (4) estimated operative time \< 120 min.

You may not qualify if:

• (1) preoperative blood pressure systolic ≥ 160 mmHg or diastolic ≥ 100 mmHg or pulse pressure ≥ 60 mmHg; (2) comorbidities of severe cardiovascular disease, including cardiac function grade III or IV, severe aortic stenosis, aortic valve insufficiency, severe coronary heart disease, bradycardia, and atrioventricular block above degree I; (3) history of cerebral infarction, Alzheimer's disease, or cerebrovascular incident; (4) liver and/or kidney dysfunction; (5) severe anemia, shock, hypovolemia, or respiratory dysfunction; (6) previous history of phlebitis or thrombosis, closed-angle glaucoma; and (7) BMI \> 25 or \< 18. Patients with intraoperative blood loss \> 1500 mL or operation time \> 4 h would be further excluded from the analysis.

Sponsors & Collaborators

• General Hospital of Ningxia Medical University: lead

Study Sites (1)

Department of Anesthesiology, General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750004, China

Location

MeSH Terms

Conditions

Shoulder Injuries

Interventions

Brachial Plexus Block; Anesthesia, General

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Nerve Block; Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Central Study Contacts

Gang Ma, doctor

CONTACT

13709519220; magang2671@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2022
• First Posted: July 11, 2022
• Study Start: July 17, 2022
• Primary Completion: September 29, 2024
• Study Completion: November 29, 2025
• Last Updated: July 19, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)