CLIC1 in Patients Presenting PD

NCT05446181 | Completed

• 1 other identifier: B-2109-706-302
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Conditions

Hip Fractures; Hip Disease

Outcome Measures

Primary Outcomes (1)

• expression pattern of CLIC1 protein

  Immediate after spinal anesthesia

Study Arms (2)

Old with perioperative delirium

Behavioral: Perioperative delirium; Procedure: Hip surgery

Old without perioperative delirium

Procedure: Hip surgery

Interventions

Perioperative delirium BEHAVIORAL

Perioperative delirium

Old with perioperative delirium

Hip surgery PROCEDURE

Orthopedic hip joint surgery under spinal anesthesia

Old with perioperative delirium; Old without perioperative delirium

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing hip joint surgery are divided into the PD group or non-PD group

You may qualify if:

• Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia

You may not qualify if:

• Patients who are unconscious
• Patients who are unable to communicate
• Alzheimer
• Parkinson Disease
• Conversion to general anesthesia

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood

MeSH Terms

Conditions

Hip Fractures

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: July 1, 2022
• First Posted: July 6, 2022
• Study Start: June 27, 2022
• Primary Completion: October 30, 2024
• Study Completion: October 30, 2024
• Last Updated: November 27, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)