Kinematic and Neuromuscular Deficiencies Phenotypes Associated With Patellofemoral Pain Syndrome

NCT05441332 | Completed

• 2 other identifiers: APHP2114332021-A01928-33
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to describe and compare the kinematic deficiencies specifically associated with each of the 3 main clinical phenotypes of patellofemoral pain syndrome. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. There are multiple classifications of patellofemoral pain syndrome. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems. The pathophysiology of patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The links between the clinical and biomechanical aspects are still unclear and the kinematic and neuromuscular deficiencies associated with the 3 main clinical phenotypes are poorly understood. A validated non-invasive device allows the 3D evaluation of femorotibial rotations during walking.

Conditions

Patellofemoral Pain Syndrome

Keywords

Patellofemoral pain syndrome; 3D Kinematics; assessment; clinical phenotypes; dynamic deficiencies

Outcome Measures

Primary Outcomes (1)

• Amplitude of rotation

  Amplitude of rotation of the femur with respect to the tibia in the bearing phase in the 3 planes of space

  Day of inclusion (up to 10 days)

Secondary Outcomes (23)

• Length measures

  Day of inclusion (up to 10 days)

• Q angle (in degree)

  Day of inclusion (up to 10 days)

• Varus valgus(in degree)

  Day of inclusion (up to 10 days)

• Peak torque (N.m)

  Day of inclusion (up to 10 days)

• Total work (N.m)

  Day of inclusion (up to 10 days)

Study Arms (1)

Patellofemoral pain syndrome

EXPERIMENTAL

Kinematic and neuromuscular assessment

Other: EOS Radiation; Behavioral: Semi-structured interview

Interventions

EOS Radiation OTHER

One EOS exam of lower extremities

Also known as: EOS X-ray exams

Patellofemoral pain syndrome

Semi-structured interview BEHAVIORAL

Semi-structured interview to identify factors influencing patient adherence behavior for a sub-group of 15 patients. By phone, between 1 to 3 months after inclusion.

Patellofemoral pain syndrome

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Medical diagnosis of SDFP :
• Anterior pain of the knee, mechanical, in front of and around the patella noted at more than 3/10 on a simple numerical scale (ligament or meniscal damage, synovial plicae, tendinopathies, apophysitis, neuromas, and osteoarthritis FT are differential diagnoses),
• Pain during any of the following activities: Going up / down stairs, squats, jumps, jogging, sitting, crouching.
• Duration of knee anterior pain greater than 1 month
• Affiliation to a social insurance
• Signature of the consent to participate

You may not qualify if:

• Neurological disorders affecting the lower extremities
• Radiographic FT osteoarthritis
• History of surgery or trauma to the lower limb less than 1 year old
• Intra-articular knee infiltration ≤ 2 months
• Cognitive or behavioral problems making it impossible to assess
• Unable to speak, read and write French
• Patients under guardianship or curatorship,
• Patients receiving AME (French State Medical aid)

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• URC-CIC Paris Descartes Necker Cochin: collaborator

Study Sites (1)

Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis - Hôpital Cochin

Paris, Île-de-France Region, 75014, France

Location

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Officials

• Marvin COLEMAN, MSc, PhD student

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 14, 2022
• First Posted: July 1, 2022
• Study Start: December 9, 2022
• Primary Completion: September 27, 2024
• Study Completion: February 27, 2025
• Last Updated: September 15, 2025

Record last verified: 2025-09

Locations

FR (1)