Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis

NCT05439317 | Completed

• 1 other identifier: 2021-09-013AC
• Study Type: observational
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.

Conditions

Knee Osteoarthritis; Elasticity Imaging Techniques

Outcome Measures

Primary Outcomes (3)

• shear modulus

  the absolute quantitative measurement of elasticity (kPa) of Hoffa's fat pad

  before and 1-3 months after hyaluronic acid injection

• strain ratio

  the semiquantitative measurement of elasticity of Hoffa's fat pad, a ratio with patellar tendon as reference

  before and 1-3 months after hyaluronic acid injection

• thickness of Hoffa's fat pad

  the thickness of Hoffa's fat pad from mid patellar tendon to femur cartilage

  before and 1-3 months after hyaluronic acid injection

Study Arms (2)

knee osteoarthritis group

individuals being diagnosed with osteoarthritis and classified by K-L grading

healthy group

individuals without knee pain or diagnosis of knee osteoarthritis

Eligibility Criteria

• Age: 20 Years - 86 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

individuals with knee osteoarthritis diagnosis is classified as K-L grading I - IV individuals in control group has no knee pain or osteoarthritis history

You may qualify if:

• OA group
• Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group
• No knee pain or received injection during the past 1 year
• No history of knee OA

You may not qualify if:

• History of knee surgery, trauma or malignancy
• History of patellar tendinopathy or patellofemoral pain syndrome
• Refused informed consent

Sponsors & Collaborators

• Taipei Veterans General Hospital, Taiwan: lead

Study Sites (1)

Taipei Veterans General Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Ding-Hao Liu

  Physical and Rehabilitation Medicine, Veterans General Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2022
• First Posted: June 30, 2022
• Study Start: December 3, 2021
• Primary Completion: April 11, 2022
• Study Completion: August 5, 2022
• Last Updated: February 22, 2023

Record last verified: 2023-02

Locations

TW (1)