(In)Voluntary Assessed Quadriceps Muscle Endurance in COPD

NCT05427773 | Completed

• 1 other identifier: 1132321
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD. We hypothesized a good correlation (\>0.8) between the measurements.

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

Peripheral muscle endurance; Electrical stimulation

Outcome Measures

Primary Outcomes (3)

• Electrically evoked fatigue resistance (%)

  Fatigue resistance (%) is the decline in muscle force generated using electrical stimulation.

  Performed in first week of pulmonary rehabilitation program

• Voluntary isometric quadriceps endurance (time to fatigue).

  Voluntary isometric quadriceps endurance (time to fatigue in seconds) is determined on the computerized dynamometer. The isometric endurance test protocol is performed by asking participants to maintain, for as long as possible, an isometric quadriceps contraction representing 60% of the individual isometric maximal voluntary contraction (MVC) force. The test will be ended if the force of the contraction was less than 50% of the MVC for three consecutive seconds.

  Performed in first week of pulmonary rehabilitation program

• Voluntary isokinetic work fatigue index.

  Voluntary isokinetic work fatigue (%) is the decline in work over 30 repetitions determined on the computerized dynamometer. The isokinetic protocol consists of 30 contractions at an angular velocity of 90°/s with maximal effort during extension and passive (submaximal) flexion. Work fatigue index = \*work first 5 repetitions - work last 5 repetitions) / work first 5 repetitions \* 100%

  Performed in first week of pulmonary rehabilitation program

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with COPD that start with the pulmonary rehabilitation program at the Radboudumc in Nijmegen.

You may qualify if:

• COPD, based on GOLD classification
• Clinically stable according to the pulmonary physician, i.e. no exacerbation and/or hospitalization within the previous 4 weeks
• Age between 40-80 years
• Take part in the pulmonary rehabilitation program at Radboudumc (Nijmegen)

You may not qualify if:

• Inability to understand the Dutch language
• Musculoskeletal and neurological problems influencing quadriceps muscle function testing

Sponsors & Collaborators

• Radboud University Medical Center: lead

Study Sites (1)

Radboudumc

Nijmegen, Gelderland, 6525 GA, Netherlands

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2022
• First Posted: June 22, 2022
• Study Start: July 5, 2022
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: February 3, 2023

Record last verified: 2022-05

Locations

NL (1)