NCT05424172

Brief Summary

The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding health apps preferences for optimal consumer use, (2) conducting a usability study of the customized app to determine the quality and implement further changes for optimization, and (3) conducting a sequential multiple assignment randomized trial (SMART) to determine the most effective adaptive intervention to improve exercise adherence. A SMART trial will be used to determine when and how to adapt dosage, timing, and delivery to increase adherence and address low-response behaviors. In Stage-I, the investigators will compare outcomes among participants using a generic, non-interactive exercise app (Group 1) to a customized, interactive app that can gain information through frequent Ecological Momentary Assessments (EMA) that will be used to modify each participant's exercise programs (Group 2). After 12 weeks, participants who are not meeting the exercise guidelines at least 50% of the time will also be asked to participate in motivational interviewing-based e-coaching either two or four times per month in addition to their originally assigned intervention (Stage-II). By completing these three phases, this project addresses deficiencies in exercise levels and compliance by implementing an individualized exercise prescription, an adaptive intervention for low responders, a way to address barriers to exercise, and a free smartphone app for broad implementation.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
4mo left

Started Nov 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress93%
Nov 2022Aug 2026

First Submitted

Initial submission to the registry

June 10, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

June 21, 2022

Completed
4 months until next milestone

Study Start

First participant enrolled

November 2, 2022

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2026

Last Updated

May 11, 2026

Status Verified

May 1, 2026

Enrollment Period

3.8 years

First QC Date

June 10, 2022

Last Update Submit

May 7, 2026

Conditions

Keywords

ExerciseTelemedicine

Outcome Measures

Primary Outcomes (2)

  • Rate of Adherence to SCI exercise guidelines

    Using app-based data and self-report, the investigators will determine if each participant met the SCI aerobic exercise guidelines (moderate to vigorous aerobic exercise for at least 20 minutes twice per week) for each week of the study. The investigators will total the number of weeks in which the participants achieved adherence and calculate the percentage of adherence over each 12-week stage. An overall adherence rate of 50% will be regarded as meeting exercise guidelines for the stage.

    12 weeks

  • Rate of Adherence to SCI exercise guidelines

    Using app-based data and self-report, the investigators will determine if each participant met the SCI aerobic exercise guidelines (moderate to vigorous aerobic exercise for at least 20 minutes twice per week) for each week of the study. The investigators will total the number of weeks in which the participants achieved adherence and calculate the percentage of adherence over each 12-week stage. An overall adherence rate of 50% will be regarded as meeting exercise guidelines for the stage.

    24 weeks

Secondary Outcomes (9)

  • Change in Six-Minute Walk/Push Test from Baseline to 12 weeks

    From Baseline to 12 weeks

  • Change in Six-Minute Walk/Push Test from 12 to 24 weeks

    From 12 weeks to 24 weeks

  • Change in Six-Minute Walk/Push Test from Baseline to 24 weeks

    From Baseline to 24 weeks

  • Change in Exercise Self-Efficacy from Baseline to 12 weeks

    From Baseline to 12 weeks

  • Change in Exercise Self-Efficacy from 12 to 24 weeks

    From 12 weeks to 24 weeks

  • +4 more secondary outcomes

Other Outcomes (6)

  • Change in 10 Meter Walk or Wheelchair Propulsion Test from Baseline to 12 Weeks

    From Baseline to 12 weeks

  • Change in 10 Meter Walk or Wheelchair Propulsion Test from 12 to 24 Weeks

    From 12 weeks to 24 weeks

  • Change in 10 Meter Walk or Wheelchair Propulsion Test from Baseline to 24 Weeks

    From Baseline to 24 weeks

  • +3 more other outcomes

Study Arms (2)

Stage-I: Self Monitoring Exercise Using a Health App

EXPERIMENTAL

Participants will be randomized into one of two groups: Group 1 (self monitoring using a non-interactive app), and Group 2 (self monitoring using an interactive app). Participants in both groups will be provided a customized exercise program to complete over the duration of the study. Within either app, participants will be able to view assigned exercises, log additional exercises completed, complete questionnaires as needed, and access additional resources. Participants will use their own smartphone to receive the health app. Participants will continue using their Stage-I app intervention for the entire duration of the study (weeks 1-24).

Behavioral: Stage-I, Group 1: Self monitoring using Non-interactive AppBehavioral: Stage-I, Group 2: Self monitoring using Interactive App

Stage-II: Strategy to Address Non-Adherence

EXPERIMENTAL

After 12 weeks, the participants will be categorized as adherents or non-adherents based on their rates of adhering to the SCI exercise guidelines during Stage-I. Non-adherents (those who met the exercise guidelines \<50% of the weeks) will be randomized to receive an augmented intervention of motivational interviewing-based e-coaching (2x per month or 4x per month) in addition to their Stage-I assigned app for 12 weeks (weeks 13-24) to further increase rates of exercise. All non-adherents who will be assigned to the e-coaching interventions will be asked to complete at least daily EMA surveys. A coach who is trained in motivational interviewing will review the EMA data and work collaboratively with participants to identify barriers and facilitators and develop individualized strategies to improve exercise adherence. Adherents (those who met the exercise guidelines \>50% of the weeks) will continue with only their Stage-I assigned app intervention throughout Stage-II.

Behavioral: Stage-II, Groups 1a/2a: E-Coaching 1x per monthBehavioral: Stage-II, Groups 1b/2b: E-Coaching 2x per month

Interventions

Participants in Group 1 will have minimal features that affect compliance (notifications, rewards, EMA, etc.) and no modifications to their exercise program after initial prescription.

Stage-I: Self Monitoring Exercise Using a Health App

Participants in Group 2 will use the version of the exercise app that has been modified based on the findings from Phases 1 and 2 of this study. Group 2 will be able to use the full features of the interactive app including notifications, ability to submit videos, and non-synchronous messaging/communicating with the researcher. Additionally, participants in Group 2 will be asked to complete 2-5 EMA-based surveys daily to gain information about the participant's barriers and facilitators to exercise. The information from the EMA questionnaires will be used to progress and modify the exercise program at regular intervals for each participant in Group 2.

Stage-I: Self Monitoring Exercise Using a Health App

In addition to the Stage-I assigned app, participants will be asked to complete at least daily EMA questionnaires and e-coaching sessions two times a month throughout Stage-II (weeks 13-24). Participants will only receive the augmented e-coaching intervention if they were not adherent to the exercise guidelines for at least 50% of the weeks during Stage-I (weeks 1-12).

Stage-II: Strategy to Address Non-Adherence

In addition to the Stage-I assigned app, participants will be asked to complete at least daily EMA questionnaires and e-coaching sessions four times a month throughout Stage-II (weeks 13-24). Participants will only receive the augmented e-coaching intervention if they were not adherent to the exercise guidelines for at least 50% of the weeks during Stage-I (weeks 1-12).

Stage-II: Strategy to Address Non-Adherence

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Individual with diagnosis of SCI, formal or informal caregiver of an individual with an SCI, or clinician that regularly sees individuals with SCI
  • years of age
  • English-speaking
  • Willing to download the study apps

You may not qualify if:

  • Severe visual or cognitive problems that would affect the ability to complete the study
  • Does not own, or is unable to use a smartphone
  • Individual with diagnosis of SCI, complete (only paraplegia) or incomplete, cervical C3- C4 and below
  • years of age
  • English-speaking
  • Use a wheelchair as primary means of mobility or walk with or without assistive equipment
  • At least 1-year post-SCI
  • Not adhering to SCI-specific exercise guidelines as ascertained by self-report or during structured phone interview
  • Interested in increasing exercise levels
  • Ownership of a smartphone that can be used for the study and has a data plan
  • Willing to successfully download and learn to use the study apps
  • Able and willing to give written consent and comply with study procedures, including multiple in person follow-up visits
  • Trauma or surgery in the past three months
  • An active stage 3 or 4 pressure ulcer
  • Medically unstable to perform the home-based exercise as determined by Dr. Chen and his team, the evaluating physical therapist, or the participants' primary care physician.
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

RECRUITING

MeSH Terms

Conditions

Spinal Cord InjuriesMotor Activity

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesTrauma, Nervous SystemWounds and InjuriesBehavior

Central Study Contacts

Sara Nataletti, PhD

CONTACT

Arun Jayaraman, PT, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SEQUENTIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 10, 2022

First Posted

June 21, 2022

Study Start

November 2, 2022

Primary Completion (Estimated)

August 31, 2026

Study Completion (Estimated)

August 31, 2026

Last Updated

May 11, 2026

Record last verified: 2026-05

Locations