Effect of Photobiomodulation on ph and Salivary Flow

NCT05413993 | Completed DMC

• 1 other identifier: PBMSF
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Changes in salivary parameters, such as decreased flow, changes in pH and composition, can lead to changes in oral health. Saliva is responsible for the homeostasis of the oral cavity and is therefore directly related to the occurrence of caries, periodontitis, fungal and bacterial infections. These situations compromise the quality of life of the population and for this reason prevention and treatment strategies need to be studied and developed. Photobiomodulation is an alternative that has been increasingly practiced by health professionals. It consists of the application of light to a biological system that is capable of inducing a photochemical process, mainly in the mitochondria, thus stimulating the production of energy in the form of adenosine triphosphate (ATP), which can increase cellular metabolism and produce effects. as analgesia and tissue regeneration. In dentistry, studies using photobiomodulation have shown promise in improving some salivary parameters. This study aimed to compare the action of infrared light on salivary flow and pH, using two application techniques: extraoral (G1) and intra and extraoral (G2), with the application interval between the two techniques being 7 days

Conditions

Xerostomia

Keywords

saliva flow; photobiomodulation

Outcome Measures

Primary Outcomes (1)

• Change in salivary flow

  The saliva was collected at the Dental Clinic of the Universidade Nove de Julho, with the adult seated at the dental team. To obtain the stimulated saliva, we used sialogogue chewing for 5 minutes, and the saliva collection was performed, by expectoration of all the saliva accumulated in the mouth every 1 minute of chewing, inside graduated glass tubes. Stimulated saliva was collected before and immediately after laser application. This procedure is performed both in the extraoral application only, and in the intra and extraoral application. After collection, 3 drops of simethicone were used to eliminate gases and foam, and only after this procedure the volume of saliva collected was measured.

  30 minutes

Secondary Outcomes (1)

• Change in pH salivary

  30 minutes

Study Arms (2)

intra and extraoral application

ACTIVE COMPARATOR

The laser was applied for 60 seconds, in 2 intraoral points and 2 extraoral points.

Radiation: photobiomodulation

extraoral application

EXPERIMENTAL

The laser was applied only extraoral points

Radiation: photobiomodulation

Interventions

photobiomodulation RADIATION

Laser application intraorals and extraoral points in the region of the salivary glands bilaterally

extraoral application; intra and extraoral application

Eligibility Criteria

• Age: 10 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adults over 18 years of age
• healthy dentition.

You may not qualify if:

• dental caries
• gingivitis or other alterations in the oral cavity
• who use medication that has the side effect of decreasing the salivary flow,
• who have used an antibiotic or anti-inflammatory within the last 30 days,
• diabetes.

Sponsors & Collaborators

• University of Nove de Julho: lead

Study Sites (1)

Nove de Julho Univ

São Paulo, São Paulo, 18133-399, Brazil

Location

MeSH Terms

Conditions

Xerostomia

Interventions

Low-Level Light Therapy

Condition Hierarchy (Ancestors)

Salivary Gland Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Model Details: QUASI-EXPERIMENTAL CLINICAL TRIAL

Study Record Dates

• First Submitted: June 2, 2022
• First Posted: June 10, 2022
• Study Start: March 10, 2022
• Primary Completion: April 10, 2022
• Study Completion: May 20, 2022
• Last Updated: June 10, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)