Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals

NCT05413837 | Unknown DMC

• 1 other identifier: CVSAV-HI
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.

Conditions

Venous Sinus Thrombosis, Cranial

Keywords

venous sinus; anatomy

Outcome Measures

Primary Outcomes (1)

• The anotomy and variation of venous sinus in Chinese healthy individuals

  According to the connection types of superior sagittal sinus and transverse sinus at the the torcular Herophili assessed with contrast-enhanced MR venography and phase-contrast MR venography, describe the anatomical classification of venous sinus based on the anatomical descriptions of Osborn and describe the anatomical variations that are not included in the existing classification. Calculating the proportion of each type.

  On the day of examination

Secondary Outcomes (2)

• The diameters of venous sinus and small veins in Chinese healthy individuals

  On the day of examination

• Serum biomarkers in Chinese healthy individuals

  On the day of examination

Interventions

anotomy and variation of venous sinus DIAGNOSTIC_TEST

Contrast enhanced-magnatic resonance venography（CE-MRV）and other magnetic resonance imaging methods are used to estimate the anatomy of cerebral venous sinus.

the level of biomarker in bood DIAGNOSTIC_TEST

Elisa or omics analysis is used to test the level of biomarker in blood.

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Chinese healthy individuals aged 18-35 years without clinical symtoms and cerebral venous diseases

You may qualify if:

• Age 18 - 35 years old.
• Confirmed no intracranial diseases, congenital abnormalities such as intracranial hematoma, tumor, vascular malformation, hydrocephalus, etc.
• Voluntarily signed informed consent.

You may not qualify if:

• Any clinical history, including hypertension, diabetes, coronary heart disease, hematologic and rheumatic immune system diseases,cervical spondylosis, anxiety, depression, insomnia, etc.
• Internal jugular venous outflow disturbance : MRV from extracranial to aortic arch demonstrates variation or stenosis of the internal jugular vein, vertebral plexus, brachiocephalic vein, and superior vena cava.
• Any history of craniocerebral trauma or surgery that affected the existence and running of veins.Unhealthy habits such as smoking, heavy drinking, etc.
• Women who are pregnant or in preparation for pregnancy or lactation.

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Xuanwu hospital;Capital Medical University

Beijin, XI Cheng District, 100053, China

RECRUITING

Related Publications (1)

• Cheng Y, Li WA, Fan X, Li X, Chen J, Wu Y, Meng R, Ji X. Normal anatomy and variations in the confluence of sinuses using digital subtraction angiography. Neurol Res. 2017 Jun;39(6):509-515. doi: 10.1080/01616412.2017.1323383. Epub 2017 May 11.

  PMID: 28494642 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples from enrolled participants are drawn by nurse using containing coagulant tubes.

MeSH Terms

Conditions

Sinus Thrombosis, Intracranial

Condition Hierarchy (Ancestors)

Intracranial Thrombosis; Intracranial Embolism and Thrombosis; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Thromboembolism; Embolism and Thrombosis

Study Officials

• Xunming Ji, MD.PhD

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xunming Ji, MD.PhD

CONTACT

010-83199430; jixm@ccmu.edu.cn

Lu Liu, MD

CONTACT

13370186128; bingtangjiaozi@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 6, 2022
• First Posted: June 10, 2022
• Study Start: July 6, 2022
• Primary Completion: August 31, 2023
• Study Completion: August 31, 2023
• Last Updated: April 18, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)