Neutrophil Side Fluorescent Light (NEU-SFL) in COVID-19 Patients
NEU-COVID
1 other identifier
observational
2,233
1 country
1
Brief Summary
Recently, a study showed that markers of neutrophil extracellular traps formation, a mechanism corresponding to neutrophil activation, were increased in patients who died of COVID 19 compared with survivors. The investigators propose to analyze the NEU-SFL parameter, obtained automatically on the Sysmex™ blood count machine (Sysmex Corporation, Kobe, Japan) and which is considered as a reflect of neutrophil extracellular traps formation, in these two groups of patients. The aim was to evaluate whether this parameter could be used to predict the risk of death related to COVID 19.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2022
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 2, 2022
CompletedFirst Submitted
Initial submission to the registry
June 9, 2022
CompletedFirst Posted
Study publicly available on registry
June 10, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedDecember 4, 2025
February 1, 2023
7 months
June 9, 2022
November 26, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021, according they survived or not.
Data collection
3 months
Secondary Outcomes (2)
Compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021 who survived, between entry and discharge from Nimes hospital
3 months
Compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021 who died, between entry and discharge from Nimes hospital
3 months
Study Arms (2)
COVID-19 survivors
Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who survived.
COVID-19 Deceased
Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who died.
Eligibility Criteria
All adult patients hospitalized for COVID-19 at Nimes Hospital in 2021.
You may qualify if:
- Hospitalization for COVID 19 in 2021
You may not qualify if:
- Patients who refused the use of their data
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Nimes
Nîmes, 30029, France
Related Publications (1)
Fortier M, Chea M, Ain C, Loyens M, Boudemaghe T, Gris JC, Bouvier S. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients? Front Med (Lausanne). 2022 Dec 21;9:1062112. doi: 10.3389/fmed.2022.1062112. eCollection 2022.
PMID: 36619613RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Anissa MEGZARI
CHU Nimes
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 9, 2022
First Posted
June 10, 2022
Study Start
June 2, 2022
Primary Completion
December 31, 2022
Study Completion
December 31, 2022
Last Updated
December 4, 2025
Record last verified: 2023-02
Data Sharing
- IPD Sharing
- Will not share