NCT05410769

Brief Summary

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the central nervous system. Second only to Alzheimer's in incidence on the population, Parkinson's disease has a negative impact on the quality of life of both patients and caregivers. Despite the prevailing attention to motor symptoms, such as bradykinesia, tremor and rigidity, the typical Parkinsonian symptom includes a wide range of non-motor symptoms that invalidate various aspects of the patient's autonomy, cognitive, behavior and mood that impact on patients' quality of life and that of caregivers.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P50-P75 for not_applicable parkinson-disease

Timeline
Completed

Started Jul 2022

Shorter than P25 for not_applicable parkinson-disease

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2022

Completed
4 months until next milestone

First Posted

Study publicly available on registry

June 8, 2022

Completed
23 days until next milestone

Study Start

First participant enrolled

July 1, 2022

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2022

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2023

Completed
Last Updated

June 8, 2022

Status Verified

June 1, 2022

Enrollment Period

2 months

First QC Date

February 17, 2022

Last Update Submit

June 5, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Compassion Mind Training online

    Patients and Caregivers report on the Compassion Scale (Gilbert P. Compassion-focused therapy: Preface and introduction for special section. Br J Clin Psychol. 2014 Mar;53(1):1-5. doi: 10.1111/bjc.12045. PMID: 24588759.). CMT is a 6-session program, each lasting about 2 hours, which run on a weekly basis. The program is organized across 3 modules: 1) Our mind according to a compassion-based approach (to provide insight into the evolved and socially shaped mind and the affect regulation systems); 2) Compassionate mind training (understanding and cultivating the attributes and competencies of compassion in its three flows, and addressing its fears); and 3) final session (revising key information and practices and its application to the online routines).

    6 weeks

Secondary Outcomes (4)

  • 2. Beck Depression Inventory - II (BDI-II)

    week 0, week 9, week 12

  • Change in quality of life

    week 0, week 9, week 12

  • Anxiety state

    week 0, week 9, week 12

  • Change from baseline in isolated heart rate variability at 12 weeks post CMT

    week 0, week 9, week 12

Study Arms (2)

PD patients

EXPERIMENTAL

The intervention envisaged by the study takes place in the form of interviews, self-reports, and measurement of the heart rate variability.

Behavioral: Compassion Focused Therapy

patient's caregivers

EXPERIMENTAL

The intervention envisaged by the study takes place in the form of interviews, self-reports, and measurement of the heart rate variability.

Behavioral: Compassion Focused Therapy

Interventions

This pilot study aims to propose for the first time a Compassion protocol (Compassion Program for Parkinson) to a group of patients with PD and a group of caregivers and to evaluate its feasibility and effectiveness. The investigators aim to assess whether the program is effective in improving the quality of life and psychiatric symptoms of the patients and caregivers. The Compassion program is a healthy form of self- acceptance, which involves being touched by one's own suffering, along with the desire to alleviate it and treat oneself with understanding and kindness. The duration of the protocol will be 6 weeks (1 meeting/ week of 2 hours). The investigators will recruit 40 patients and 20 caregivers who will be assessed pre and post intervention (Compassionate Mind Training) with interviews, self reports and measurement of the heart rate variability.

PD patientspatient's caregivers

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • PD diagnosis according to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria (UKPDS)
  • Ability to provide written informed consent
  • Age between 18 and 80 years (inclusive)

You may not qualify if:

  • cognitive impairment
  • Inability to provide written informed consent
  • any cardiological condition/drugs that alter the heartbeat
  • Diagnosis of other concomitant neurodegenerative disease or psychiatric diaseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Gilbert P. Compassion-focused therapy: Preface and introduction for special section. Br J Clin Psychol. 2014 Mar;53(1):1-5. doi: 10.1111/bjc.12045. No abstract available.

    PMID: 24588759BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Central Study Contacts

Nicola Modugno, MD

CONTACT

Silvia Della Morte, psychologist

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

February 17, 2022

First Posted

June 8, 2022

Study Start

July 1, 2022

Primary Completion

September 1, 2022

Study Completion

May 1, 2023

Last Updated

June 8, 2022

Record last verified: 2022-06