The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

NCT05409885 | Completed

• 1 other identifier: 5/4
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Conditions

Anesthesia, General; Anesthesia, Spinal; Umbilical Cord

Keywords

anesthesia; cesarean section; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; mean platelet volume

Outcome Measures

Primary Outcomes (1)

• neutrophil-to-lymphocyte ratio

  Evaluate the effects of NLR in patients undergoing cesarean section

  within 5 minute, following delivery

Secondary Outcomes (4)

• platelet-to-lymphocyte ratio

  within 5 minute, following delivery

• mean platelet volume

  within 5 minute, following delivery

• Newborn Apgar score 1st minute

  1st minute after birth

• Newborn Apgar score 5th minute

  5th minute after birth

Study Arms (2)

General anesthesia group

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Other: General anesthesia

Spinal anesthesia group

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Other: Spinal anesthesia

Interventions

General anesthesia OTHER

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

General anesthesia group

Spinal anesthesia OTHER

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Spinal anesthesia group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

elective ceserean surgery

You may qualify if:

• years
• American Society of Anesthesiology (ASA) II-III
• elective ceserean surgery

You may not qualify if:

• declining to give written informed consent
• under 18 years of age or over 45 years of age
• factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
• history of neurological and/or neuromucular disease
• cooperation cannot be established
• emergency surgery

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

Study Sites (1)

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation

Antalya, 07100, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Anesthesia, General; Anesthesia, Spinal

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia; Anesthesia, Conduction

Study Officials

• Kerem İnanoğlu

  Antalya TRH

  PRINCIPAL INVESTIGATOR

• Esra Bağ

  Antalya TRH

  PRINCIPAL INVESTIGATOR

• Arzu Karaveli

  Antalya TRH

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2022
• First Posted: June 8, 2022
• Study Start: March 20, 2022
• Primary Completion: July 1, 2022
• Study Completion: July 7, 2022
• Last Updated: July 21, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)