Subclinical Hypothyrodism and Ovarian Reserve
Evaluation of Ovarian Reserve in Women With Subclinical Hypothyrodism in Reproductive Age
1 other identifier
observational
300
1 country
1
Brief Summary
This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve Primary outcome: Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2016
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2020
CompletedFirst Submitted
Initial submission to the registry
June 4, 2022
CompletedFirst Posted
Study publicly available on registry
June 8, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2023
CompletedJune 8, 2022
June 1, 2022
4 years
June 4, 2022
June 4, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)
This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve
48 months
Interventions
Eligibility Criteria
patients with thyroid dysfunction who seeking fertility
You may qualify if:
- All reproductive age groups included women less than 35 and women more than 35
You may not qualify if:
- Previous ovarian surgery Women with long term thyroid hormone replacement Endometriosis History of radiotheraby
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Assiut Medical School
Asyut, 71511, Egypt
Related Publications (2)
Rao M, Wang H, Zhao S, Liu J, Wen Y, Wu Z, Yang Z, Su C, Su Z, Wang K, Tang L. Subclinical Hypothyroidism Is Associated with Lower Ovarian Reserve in Women Aged 35 Years or Older. Thyroid. 2020 Jan;30(1):95-105. doi: 10.1089/thy.2019.0031. Epub 2019 Dec 20.
PMID: 31650898RESULTKorevaar TIM, Minguez-Alarcon L, Messerlian C, de Poortere RA, Williams PL, Broeren MA, Hauser R, Souter IC. Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care. Thyroid. 2018 Oct;28(10):1349-1358. doi: 10.1089/thy.2017.0582. Epub 2018 Aug 14.
PMID: 29943679RESULT
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
June 4, 2022
First Posted
June 8, 2022
Study Start
January 1, 2016
Primary Completion
January 1, 2020
Study Completion
August 1, 2023
Last Updated
June 8, 2022
Record last verified: 2022-06
Data Sharing
- IPD Sharing
- Will not share