Perioperative Eosinophils Their Recovery in Type A Acute Aortic Dissection Prognosis

NCT05409677 | Completed

• 1 other identifier: 81871607
• Study Type: observational
• Target: 274
• Locations: 1 country
• Sites: 2

Brief Summary

Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death during the acute phase. Currently, little evidence is available with regards to the relationship between eosinophils (EOS) and TA-AAD. A total of 274 patients with TA-AAD were eligible for inclusion and 54 patients deceased within 1 month following surgery. Multivariate regression analysis, the general linear model repeated-measures ANOVA analysis (corrected by Greenhouse-Geisser test), receiver-operating characteristics (ROC) curves and a Kaplan-Meier curve were applied for statistical analysis.

Conditions

Acute Aortic Dissection

Keywords

Type A acute aortic dissection; Eosinophils; Prognosis

Outcome Measures

Primary Outcomes (1)

• mortality

  The primary outcome was 1-month mortality

  The first month after operation

Secondary Outcomes (1)

• Infection and in-hospital poor prognosis

  An average of 1 year

Study Arms (1)

1-month survivors; 1-month non-survivors

Depending on mortality within 1 month, the patients were divided into two groups named 1-month survivors and 1-month non-survivors.There was no intervention other than normal treatment

Other: This was a retrospective study with no intervention other than normal treatment

Interventions

This was a retrospective study with no intervention other than normal treatment OTHER

This was a retrospective study with no intervention other than normal treatment

1-month survivors; 1-month non-survivors

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients were dignosed with Type A acute aortic dissection by the computer tomography between February 2019 and July 2021. A total of 54 patients deceased unfortunately within 1 month following surgery. Depending on mortality within 1 month, the baseline characteristics was compared. Patients were 51.58±11.57 years of age, 203(74.1%) men, and 161(58.8%) with hypertension. There was no discernible difference in gender, BMI, smoking, and alcohol consumption (P\>0.05). Moreover, in addition to renal insufficiency, medical histories showed no remarkable deviations between the aforementioned two groups. Non-survivors within 1 month were more likely to have renal insufficiency (6.8% vs. 20.4%; P=0.005).

You may qualify if:

• The patients with a diagnosis of Type A acute aortic dissection by the computer tomography

You may not qualify if:

• History of cardiogenic shock or cardiac tamponade;
• Iatrogenic aortic dissection;
• Traumatic aortic dissection;
• Severe valvular disease;
• Congenital heart disease;
• Severe organ dysfunction, such as liver and kidney failure;
• Metabolic diseases such as gout or hyperthyroidism;
• Malignant tumor;
• Severe gastrointestinal diseases;
• Recent drug usage that might affect EOS;
• Allergic diseases;
• Infectious diseases;
• Skin diseases;
• Hematological diseases, such as leukemia and myelodysplastic syndromes;
• Immune system diseases.

Sponsors & Collaborators

• First Affiliated Hospital Xi'an Jiaotong University: lead

Study Sites (2)

First Affiliated Hospital of Xian JiaotongUniversity

Xi'an, Shaanxi, 710061, China

Location

First Affiliated Hospital of Xiann JiaotongUniversity

Xi'an, Shaanxi, 710061, China

Location

Related Publications (1)

• Wang X, Zhu Y, Ma X, Ren J, Yan Y, Liu Y, Gao H, Zhang S, Chen Y, Yang Y, Deng C. Eosinophil Recovery Time Is Associated with Clinical Outcomes in Patients with Type A Acute Aortic Dissection: a Retrospective Cohort Study. J Cardiovasc Transl Res. 2024 Jun;17(3):723-731. doi: 10.1007/s12265-023-10468-5. Epub 2024 Apr 15.

  PMID: 38622370 DERIVED

Study Officials

• Yang Yan, Doctor

  First Affiliated Hospital Xi'an Jiaotong University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2022
• First Posted: June 8, 2022
• Study Start: February 1, 2019
• Primary Completion: April 6, 2021
• Study Completion: June 7, 2021
• Last Updated: June 8, 2022

Record last verified: 2022-05

Locations

CN (2)