Intercellular Adhesion Molecule-1 and TNF-α in Patients With COVID-19

NCT05408325 | Completed

• 1 other identifier: TEJB-D-22-00066
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to assess the cytokine profile in COVID 19 patients and its relation with disease progression \& severity using COVID reporting and data system (CORADS) score.

Conditions

COVID-19; Cytokine Storm

Keywords

Covid19; ICAM; Cytokines; TNF

Outcome Measures

Primary Outcomes (1)

• Measure level of ICAM 1 and TNFα in RT PCR positive COVID 19 patients

  Quantitative detection for tumor necrosis factor alfa (TNF-α) \& intercellular adhesion molecule1 (ICAM-1) was performed using ELISA kits ( Bio reader by thermo fisher scientific Waltham, MA USA) according to the manufacture instructions.

  12 month

Study Arms (2)

confirmed COVID 19 ptients

All patients confirmed by RT-PCR, as positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who visited the emergency room and the outpatient clinic in the study period.

healthy subjects

normal healthy volunteers

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Mild pneumonia was confirmed by positive (qRT-PCR) tests, with no chest tomography features of viral pneumonia, moderate cases had pneumonia in CT chest while severe pneumonia was diagnosed as pneumonia plus 1 of these criteria: (1) respiratory rate ≥ 30 breath per minute with respiratory distress ;(2) saturation of oxygen ≤ 92 % at rest; (3) index of oxygenation ≤ 300 mmHg; (4) respiratory failure that require ventilation;(5) shock; and(6) admission to the ICU unit for other organ failure. CORAD score was calculated for all cases and was included in the radiology report. The degree of suspicion ranged from very low to very high (CO-RADS categories 1-5), while category 0 reflects negative infection and category 6 establishes RT-PCR-positive SARS-Cov-2 infection at time of examination 13.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Benha University hospital

Banhā, Kalyobia, 13512, Egypt

Location

MeSH Terms

Conditions

COVID-19; Cytokine Release Syndrome

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor of chest diseases and tuberculosis

Study Record Dates

• First Submitted: June 4, 2022
• First Posted: June 7, 2022
• Study Start: February 1, 2021
• Primary Completion: December 30, 2021
• Study Completion: February 12, 2022
• Last Updated: June 14, 2022

Record last verified: 2022-06

Locations

EG (1)