Lymphocyte Count and High Fluorescent Count (HFLC) Correlate With Liver Disorder in Dengue Fever Patients

NCT05407181 | Unknown DMC

• 1 other identifier: DHFandHFLC
• Study Type: observational
• Target: 11
• Locations: 1 country
• Sites: 2

Brief Summary

Liver dysfunction marked by elevated alanine transaminase enzymes is quite common in dengue patients and subsequently affects the disease's severity and healing process. Unfortunately, liver function tests cannot always be done, especially in hospitals with limited facilities. In contrast, routine hematology tests are considered regular and inexpensive tests that can be performed on dengue patients. Therefore, this study aims to determine hematological parameters as markers of elevated liver enzymes in dengue patients.

Conditions

Dengue Fever

Outcome Measures

Primary Outcomes (2)

• Correlation of SGPT/ALT with Lymphocytes

  Correlation of SGPT/ALT with Lymphocytes

  May 30-June 5 2022

• Correlation of SGPT/ALT with HFLC

  Correlation of SGPT/ALT with HFLC

  May 30-June 5 2022

Interventions

Blood and Liver Function test OTHER

Data was collected through routine blood and liver function tests using a hematology analyzer and ELISA, respectively.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study is a cross-sectional study involving 11 dengue fever patients, consisting of 9 men and 2 women at Sebelas Maret University Hospital (RS UNS), Sukoharjo.

You may qualify if:

• patients who were hospitalized at UNS Hospital with the following criteria: (1) adult patients (19-65 years); (2) diagnosed with dengue hemorrhagic fever according to WHO 2011 criteria; (3) routine blood examination at least once in seven days since the onset of fever; and (4) checked alanine transaminase and aspartate transaminase levels at least once in seven days from the onset of fever.

Sponsors & Collaborators

• Nurhasan Agung Prabowo: lead

Study Sites (2)

RS UNS (Universitas Sebelas Maret Hospital)

Sukoharjo, Central Java, 57161, Indonesia

RECRUITING

Universitas Sebelas Maret Hospital

Sukoharjo, Central Java, 57161, Indonesia

RECRUITING

MeSH Terms

Conditions

Dengue

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Mosquito-Borne Diseases; Vector Borne Diseases; Infections; Arbovirus Infections; Virus Diseases; Flavivirus Infections; Flaviviridae Infections; RNA Virus Infections; Hemorrhagic Fevers, Viral

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Nurhasan Agung Prabowo, MD

  Universitas Sebelas Maret

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nurhasan Agung Prabowo, MD

CONTACT

6282328010430; dr.Nurhasan21@staff.uns.ac.id

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: dr. Nurhasan Agung Prabowo, Sp.PD

Study Record Dates

• First Submitted: June 1, 2022
• First Posted: June 7, 2022
• Study Start: June 3, 2022
• Primary Completion: June 3, 2022
• Study Completion: June 5, 2022
• Last Updated: June 7, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

ID (2)