Improving Care and Community Representation for Adolescents and Young Adults Living With HIV in West Africa

NCT05405322 | Active Not Recruiting

• 1 other identifier: 999999
• Study Type: observational
• Target: 267
• Locations: 2 countries
• Sites: 4

Brief Summary

Context: HIV-positive young people aged 15 to 24 are a heterogeneous population in terms of gender, age, mode of transmission, sexual orientation and risk-taking. This most vulnerable age group is at greater risk of disruption of medical care and poor compliance, and has greater needs for psychosocial support and differentiated health services. It remains highly invisible in West African countries, both in the definition of care policies and in the allocation of resources and community representation. Objectives: The overall objective of the project is to contribute to the improvement of retention in care, health and well-being of adolescents and young adults living with HIV (AYAHIV) and to support their integration into the community space. SO1: Support the operationalisation of the transition of HIV-infected adolescents from paediatrics to adult medical services in a stakeholder inclusive, participatory and responsive approach SO2: Contribute to the empowerment and autonomy of adolescents and young adults living with HIV in the project environment SO3: Contribute to the generation and dissemination of evidence-based information and recommendations on the situation and needs of adolescents and young adults, including key populations, living with HIV Target: Approximately 67 caregivers∙e∙s ≥ 25 years old, of which 64%F, 30 peer-referent associations of 20-24 years old (ratio F/H= 1:1), 700 AYAHIV ≥ 15 years old, of which 47%F, in paediatrics and 500-600 AYAHIV aged 15-24 years old in adult medicine, of which 41%F, and including AYAHIV associations Summary of activities: Based on the capitalisation and pooling of experiences of partner teams, the project proposes to support the implementation of transition in a pragmatic approach, adapted to the needs of adolescents and inclusive of carers, adolescents and community peers. More globally, it contributes to improving the health, empowerment and autonomy of HIV-positive youth, including key populations, in particular through support to training, structuring and community representation of youth associations, documentation of the conditions of entry into care and their specific needs, including digital health, production and availability of evidence and recommendations in this West African context and advocacy building. A multidisciplinary and participatory research-action project, carried out by the IRD in Senegal and financed by Sidaction, accompanies the three specific objectives of the project.

Conditions

HIV Infections; Adolescent Behavior; Transition

Keywords

adolescent; HIV infection; transition; west africa; community; peer

Outcome Measures

Primary Outcomes (2)

• retention in care

  percent of adolescents who remain in care

  Month 12

• retention in care

  percent of adolescents who remain in care

  Month 21

Secondary Outcomes (5)

• virologic suppression

  Month 12

• virologic suppression

  Month 21

• quality of life in relation to health

  Month 12

• quality of life in relation to health

  Month 21

• level of preparedness to adult care

  Month 12

Eligibility Criteria

• Age: 15 Years - 24 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The target population of the study is all HIV-infected adolescents (mainly through mother-to-child transmission) aged 15 to 24 years, eligible for transition to care and followed up in the active files of reference centers that are members of the EVA network in Senegal and Burkina Faso.

You may qualify if:

• being HIV-infected
• aged 15 to 24 years
• on antiretroviral treatment
• HIV status disclosed
• caretaker's written consent (if \< 18 years)
• adolescent's written consent

You may not qualify if:

• mental illness

Sponsors & Collaborators

• Institut de Recherche pour le Developpement: lead
• Sidaction: collaborator
• EXPERTISE FRANCE, Paris France: collaborator
• Children and HIV Network in AFRICA (EVA), Dakar Senegal: collaborator
• Cheikh Anta Diop University, Senegal: collaborator

Study Sites (4)

CHU CDG

Ouagadougou, Burkina Faso

Location

CHU YO

Ouagadougou, Burkina Faso

Location

Chnear Albert Royer

Dakar, 00000, Senegal

Location

Centre hospitalier Roi Baudouin

Guédiawaye, Senegal

Location

MeSH Terms

Conditions

HIV Infections; Adolescent Behavior

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: November 10, 2021
• First Posted: June 6, 2022
• Study Start: April 7, 2021
• Primary Completion: January 1, 2023
• Study Completion: December 31, 2024
• Last Updated: June 28, 2024

Record last verified: 2024-06

Locations

BU (2); SE (2)