Arizona Alzheimer's Disease Research Center (ADRC)
1 other identifier
observational
550
1 country
5
Brief Summary
The Arizona Alzheimer's Disease Research Center (ADRC) is the National Institute on Aging's (NIA's) first statewide AD Center (ADC), the only ADC in the Southwestern United States, and a leading example of statewide collaboration in biomedical research. It capitalizes on Arizona's strengths in brain imaging, genomics, computer science and biomathematics, the basic, cognitive and behavioral neurosciences, clinical, and neuropathological studies of AD, the discovery and evaluation of investigational treatments, and the study of normal cognitive aging.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2021
Longer than P75 for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2021
CompletedFirst Submitted
Initial submission to the registry
March 4, 2022
CompletedFirst Posted
Study publicly available on registry
June 6, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2026
CompletedAugust 19, 2024
July 1, 2024
4.7 years
March 4, 2022
August 16, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Cognitive Status
The ADRC uses a prospective, standardized, and longitudinal clinical evaluation of participants to determine their cognitive status. This includes tests that assess short and long term memory, ability to complete daily tasks, and processing of information.
12 months
Eligibility Criteria
The Clinical Core maintains a target of 550 participants at all stages of the aging-dementia spectrum including 400 normal controls and 150 participants with MCI, probable AD dementia and other dementias. Embedded within these diagnostic categories are defined Latino and Native American cohorts. Participants will be referred to the ADRC from varying sources including, but not limited to, clinic referrals, community outreach programs, general advertising, national registries, and other sites within the consortium. Participants eligible for enrollment and those completing annual follow-up are discussed in frequent diagnostic consensus conferences. All undergo a standardized neuropsychological and neurological battery of tests at entry and annual tests at all sites.
You may qualify if:
- Cognitively normal persons, individuals with mild cognitive impairment or dementia who are at least 40 years of age.
- Willing to undergo health and cognitive assessments, and collection and banking of blood with venipuncture for genetic research, biomarker research, and DNA banking.
You may not qualify if:
- \. Participants whose diagnosis is unclear and confounded by multiple possible factors are excluded. Participants with diagnoses of non-AD dementias are not excluded.
- \. Participants whose primary diagnosis is cognitive impairment due to a penetrating or single severe closed head injury, multiple sclerosis, brain tumor, metabolic or toxic encephalopathy, post-infectious (e.g., viral encephalitis, bacterial meningitis), paraneoplastic, primary psychiatric illness, or otherwise not deemed relevant to the intent of the Alzheimer Disease Center program are excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Banner Healthlead
Study Sites (5)
Banner Alzheimer's Institute
Phoenix, Arizona, 85006, United States
Barrow Neurological Institute
Phoenix, Arizona, 85013, United States
Mayo Clinic
Scottsdale, Arizona, 85259, United States
Banner Sun Health Research Institute
Sun City, Arizona, 85351, United States
Banner Alzheimer's Institute - Tucson
Tucson, Arizona, 85718, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 4, 2022
First Posted
June 6, 2022
Study Start
October 1, 2021
Primary Completion
June 30, 2026
Study Completion
June 30, 2026
Last Updated
August 19, 2024
Record last verified: 2024-07