Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients

NCT05403489 | Completed DMC

• 1 other identifier: HisarIH
• Study Type: observational
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed. Isolation of the agent with bronchoalveolar lavage (BAL) culture or endotracheal aspirate (ETA) culture may increase the success of treatment. This study aimed to retrospectively analyze the results of BAL and ETA cultures in intubated COVID-19 cases. Methods: We routinely apply BAL culture with bronchoscopy or ETA culture within the first 48 hours after intubating. We retrospectively screened cases who underwent BAL and ETA. They were divided into two groups: Group B and E. Evaluated parameters were compared in both groups. Results: Demographic data and blood test results were similar in both groups. Intensive care unit (ICU) and intubation durations, and culture positivity were statistically significantly higher in Group B. Although not statistically significant, the mortality rate was higher in Group E. The most growth microorganisms were Candida species. Conclusion: Mortality rates were consistent with the literature. Since the microorganism isolation rate is higher with BAL and antimicrobial treatment is applied more effectively; early deaths were prevented and stay periods were prolonged. In contrast, these durations were shorter in the ETA group due to higher mortality. In intubated COVID-19 cases, a more effective treatment process can be carried out by clearing the airway with fiberoptic bronchoscopy and by specifically planning the treatment according to the BAL culture. This may have a positive effect on prognosis and mortality.

Conditions

Bronchoalveolar Lavage; COVID-19 Pneumonia; Critical Illness

Outcome Measures

Primary Outcomes (4)

• Culture positivity

  Significantly higher microbiological culture growth rate was obtained in Group B

  1 years

• Length of stay in intensive care unit

  Significantly higher duration of stay in intensive care unit was found in Group B

  1 years

• Duration of intubation

  Significantly higher duration of stay intubated was observed in Group B

  1 years

• Mortality

  Mortality rate was higher in Group E. But not statistically significant.

  1 years

Secondary Outcomes (1)

• Microorganism

  1 years

Study Arms (2)

Group B (bronchoalveolar lavage)

Patients who underwent BAL\* were named Group B \* BAL: bronchoalveolar lavage

Procedure: Bronchoalveolar lavage

Group E (endotracheal aspirate)

Patients who received ETA\*\* were named Group E. \*\* ETA: Endotracheal aspirate

Procedure: endotracheal aspirate culture

Interventions

Bronchoalveolar lavage PROCEDURE

In cases approved for bronchoscopy, bronchoalveolar lavage was performed and culture analysis was performed.

Also known as: Bronchoalveolar lavage culture, fiberoptic bronchoscopy

Group B (bronchoalveolar lavage)

endotracheal aspirate culture PROCEDURE

In cases where consent for bronchoscopy could not be obtained, tracheal secretions were aspirated and culture analysis was performed.

Group E (endotracheal aspirate)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients who were intubated due to COVID 19 in our reanimation unit between January 2021 and December 2021 and underwent BAL or ETA analysis were retrospectively scanned from the hospital information management system and patient files.

You may qualify if:

• Intubated COVID-19 patients
• Above 18 years old patients

You may not qualify if:

• Non COVID-19 patients
• Non intubated COVID-19 patients
• Below 18 years old patients

Sponsors & Collaborators

• Basri Cakiroglu: lead

Study Sites (1)

Hisar Intercontinental Hospital

Istanbul, 34768, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness

Interventions

Bronchoalveolar Lavage

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Therapeutic Irrigation; Investigative Techniques

Study Officials

• Hasan Huseyin Kilic

  Hisar Intercontinental Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Hisar Intercontinental Hospital

Study Record Dates

• First Submitted: June 2, 2022
• First Posted: June 3, 2022
• Study Start: January 1, 2021
• Primary Completion: December 31, 2021
• Study Completion: May 31, 2022
• Last Updated: June 3, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)