The Objective Assessment and Characteristics of Dry Nose From Clinical Perspective

NCT05401344 | Completed

• 1 other identifier: V 1.0
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

In the present study, we propose objective diagnostic criteria for dry nose (DN) and investigate its characteristics. Questionnaires were completed by each participant during recruitment to record demographic data. DN test strips were used to evaluate the severity of DN at five time points and allergic status was assessed based on serum sIgE levels. Nasal secretions were collected and vasomotor rhinitis was diagnosed using the cold dry air test. The diagnosis of allergic rhinitis (AR) was based on the criteria of the Allergic Rhinitis and its Impact on Asthma consensus statement. Data are expressed as median and interquartile range, unless otherwise specified. Statistical significance was set at P \< 0.05. The reference range (RR) of the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles were determined for each test strip length at each time point. This study aimed to investigate the characteristics of and propose objective diagnostic criteria for DN.

Conditions

Diagnostic Self Evaluation

Outcome Measures

Primary Outcomes (1)

• The length of the test strip.

  We propose that the diagnostic criterion for DN is a strip length less than 17.0 mm at 5 min.

  5 minutes

Study Arms (2)

dry nose patients

Diagnostic Test: test strips,sponges and cold dry air test

normal controls

Diagnostic Test: test strips,sponges and cold dry air test

Interventions

test strips,sponges and cold dry air test DIAGNOSTIC_TEST

Test strips were used to evaluated the degree of dry nose, sponges were used to obtain the nasal secretion and cold dry air test was used to making diagnosis of vasomotor rihinitis.

dry nose patients; normal controls

Eligibility Criteria

• Age: 23 Years - 73 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Overall, 20 patients (13 men and seven women) with dry nose and 100 controls (47 men and 53 women) were recruited for the study. The ages of the participants ranged from 23 to 73 years (mean = 47.7 years).

You may qualify if:

• Clinical diagnosis of dry nose patients.

You may not qualify if:

• chronic rhinosinusitis and/or nasal polyposis, allergic fungal rhinosinusitis, immunological disease, tumor patients, pregnant women.

Sponsors & Collaborators

• Beijing Tongren Hospital: lead

Study Sites (1)

Yifan Meng

Beijing, Beijing Municipality, 010, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 26, 2022
• First Posted: June 2, 2022
• Study Start: December 11, 2018
• Primary Completion: July 24, 2021
• Study Completion: October 31, 2021
• Last Updated: June 2, 2022

Record last verified: 2018-12

Locations

CN (1)